Cancer progression with uncontrolled tumor growth, local invasion, and metastasis depends
largely on the proteolytic activity of numerous matrix metalloproteinases (MMPs), which …

Sarcopenic obesity and diabetes are two increasing health problems worldwide, which both
share many common risk factors, such as aging, and general obesity. The pathogenesis of …

Matrix metalloproteinases (MMPs) are identifiable members of proteolytic enzymes that can
degrade a wide range of proteins in the extracellular matrix (ECM). MMPs can be …

The incidence of diabetes and cancer has increased significantly in recent years.
Furthermore, there are many common risk factors for both diabetes and cancer, such as …

Cancer is one of the leading causes of mortality worldwide. PPAR modulators may hold
great potential for the management of cancer patients. Indeed, PPARs are critical sensors …

TGF-β is secreted in the tumour microenvironment in a latent, inactive form bound to latency
associated protein and activated by the integrin αV subunit. The activation of latent TGF-β by …

Knee osteoarthritis (KOA) is a degenerative disease, making a unique contribution to
chronic pain, edema, and limited mobility of knee joint. Traditional Chinese Medicine (TCM) …

The unique optoelectronic and tunable luminescent characteristics of copper nanoclusters
(Cu NCs) make them extremely promising as luminophores. However, the limited …

The tumor microenvironment (TME) has become the focus of interest in cancer research and
treatment. It includes the extracellular matrix (ECM) and ECM-modifying enzymes that are …

Cancer is complicated to treat because of its high propensity for recurrence and metastasis,
and various side effects of conventional cancer treatments. With the development of …