Amoebiasis is the second leading cause of death from parasitic disease worldwide. The
causative protozoan parasite, Entamoeba histolytica, is a potent pathogen. Secreting …

A revised six-kingdom system of life is presented, down to the level of infraphylum. As in my
1983 system Bacteria are treated as a single kingdom, and eukaryotes are divided into only …

A plethora of apoptotic stimuli converge on the mitochondria and affect their membrane
integrity. As a consequence, multiple death-promoting factors residing in the mitochondrial …

Viewed through the lens of the genome it contains, the mitochondrion is of unquestioned
bacterial ancestry, originating from within the bacterial phylum α-Proteobacteria …

A new hypothesis for the origin of eukaryotic cells is proposed, based on the comparative
biochemistry of energy metabolism. Eukaryotes are suggested to have arisen through …

Molecular phylogenetics has revolutionized our knowledge of the eukaryotic tree of life. With
the advent of genomics, a new discipline of phylogenetics has emerged: phylogenomics …

The idea that some eukaryotes primitively lacked mitochondria and were true intermediates
in the prokaryote-to-eukaryote transition was an exciting prospect. It spawned major …

▪ Abstract Recent results from ancestral (minimally derived) protists testify to the tremendous
diversity of the mitochondrial genome in various eukaryotic lineages, but also reinforce the …

▪ Abstract Microsporidia are a large group of microbial eukaryotes composed exclusively of
obligate intracellular parasites of other eukaryotes. Almost 150 years of microsporidian …

The presence of shared conserved insertion or deletions (indels) in protein sequences is a
special type of signature sequence that shows considerable promise for phylogenetic …