Advances in the study of brain development over the last decades, especially recent findings
regarding the evolutionary expansion of the human neocortex, and large-scale analyses of …

Mechanisms that ensure robust long-term performance of synaptic transmission over a wide
range of activity are crucial for the integrity of neuronal networks, for processing sensory …

Synaptic vesicles fuse at active zone (AZ) membranes where Ca2+ channels are clustered
and that are typically decorated by electron-dense projections. Recently, mutants of the …

The brain is programmed to drive behaviour by precisely wiring the appropriate neuronal
circuits. Wiring and rewiring of neuronal circuits largely depends on the orchestrated …

Nervous system function relies on the polarized architecture of neurons, established by
directional transport of pre-and postsynaptic cargoes. While delivery of postsynaptic …

The study of synaptic specificity and plasticity in the CNS is limited by the inability to
efficiently visualize synapses in identified neurons using light microscopy. Here, we describe …

The regulated release of neurotransmitter occurs via the fusion of synaptic vesicles (SV s) at
specialized regions of the presynaptic membrane called active zones (AZ s). These regions …

The dynamics of exocytosis are diverse and have been optimized for the functions of
synapses and a wide variety of cell types. For example, the kinetics of exocytosis varies by …

Active zones (AZs) are presynaptic membrane domains mediating synaptic vesicle fusion
opposite postsynaptic densities (PSDs). At the Drosophila neuromuscular junction, the ELKS …

The location, size, and number of synapses critically influence the specificity and strength of
neural connections. In axons, synaptic vesicle (SV) and active zone (AZ) proteins are …