Schizophrenia is a severe neuropsychiatric disorder with a longstanding history of
neurobiological investigation. Although the underlying causal mechanisms remain …

The ability to model human brain development in vitro represents an important step in our
study of developmental processes and neurological disorders. Protocols that utilize human …

Parkinson's disease (PD) is the second most prevalent neurological disorder and has been
the focus of intense investigations to understand its etiology and progression, but it still lacks …

Human pluripotent stem cells (PSCs) provide a unique entry to study species-specific
aspects of human disorders such as Alzheimer's disease (AD). However, in vitro culture of …

Significance: Our current knowledge of the pathophysiology and molecular mechanisms
causing psychiatric disorders is modest, but genetic susceptibility and environmental factors …

Neurological disorders are the leading cause of disability and the second largest cause of
death worldwide. Despite significant research efforts, neurology remains one of the most …

Heterozygous loss-of-function mutations in SHANK2 are associated with autism spectrum
disorder (ASD). We generated cortical neurons from induced pluripotent stem cells derived …

Defined genetic models based on human pluripotent stem cells have opened new avenues
for understanding disease mechanisms and drug screening. Many of these models assume …

Neurological disorders have emerged as a predominant healthcare concern in recent years
due to their severe consequences on quality of life and prevalence throughout the world …

Three-dimensional (3D) tissue modeling is an emerging field of investigation for disease
mechanisms, drug testing, and therapeutic effects for human survival. Various methods have …