New insights into the epidemiology of childhood atopic dermatitis

C Flohr, J Mann - Allergy, 2014 - Wiley Online Library
There is a growing desire to explain the worldwide rise in the prevalence of atopic dermatitis
(AD). Trend data on the burden of AD suggest that the picture in the develo** world may …

Helminth infections and host immune regulation

HJ McSorley, RM Maizels - Clinical microbiology reviews, 2012 - journals.asm.org
Helminth parasites infect almost one-third of the world's population, primarily in tropical
regions. However, regions where helminth parasites are endemic record much lower …

The exposome in atopic dermatitis

N Stefanovic, C Flohr, AD Irvine - Allergy, 2020 - Wiley Online Library
Atopic dermatitis (AD) is a complex inflammatory disorder with multiple interactions between
genetic, immune and external factors. The sum of external factors that an individual is …

Pathophysiology of allergic inflammation

PJ Barnes - Immunological reviews, 2011 - Wiley Online Library
Allergic inflammation is due to a complex interplay between several inflammatory cells,
including mast cells, basophils, lymphocytes, dendritic cells, eosinophils, and sometimes …

Human toxocariasis: diagnosis, worldwide seroprevalences and clinical expression of the systemic and ocular forms

G Rubinsky-Elefant, CE Hirata… - Annals of Tropical …, 2010 - Taylor & Francis
Although human toxocariasis ranks among the most common zoonotic infections worldwide,
it remains relatively unknown to the public. The causal agents are the nematode parasites …

Helminth therapy or elimination: epidemiological, immunological, and clinical considerations

LJ Wammes, H Mpairwe, AM Elliott… - The Lancet Infectious …, 2014 - thelancet.com
Deworming is rightly advocated to prevent helminth-induced morbidity. Nevertheless, in
affluent countries, the deliberate infection of patients with worms is being explored as a …

The role of the environmental risk factors in the pathogenesis and clinical outcome of atopic dermatitis

D Bonamonte, A Filoni, M Vestita… - BioMed research …, 2019 - Wiley Online Library
Atopic dermatitis (AD) prevalence is rising worldwide. Literature data suggest the incidence
of AD in develo** countries is gradually getting close to that of developed ones, in which …

Helminth allergens, parasite-specific IgE, and its protective role in human immunity

CM Fitzsimmons, FH Falcone, DW Dunne - Frontiers in immunology, 2014 - frontiersin.org
The Th2 immune response, culminating in eosinophilia and IgE production, is not only
characteristic of allergy but also of infection by parasitic worms (helminths). Anti-parasite IgE …

Research needs in allergy: an EAACI position paper, in collaboration with EFA

NG Papadopoulos, I Agache, S Bavbek, BM Bilo… - Clinical and translational …, 2012 - Springer
In less than half a century, allergy, originally perceived as a rare disease, has become a
major public health threat, today affecting the lives of more than 60 million people in Europe …

The role of the environment and exposome in atopic dermatitis

N Stefanovic, AD Irvine, C Flohr - Current Treatment Options in Allergy, 2021 - Springer
Purpose of review Atopic dermatitis (AD) is a chronic inflammatory skin disorder affecting up
to 20% of children and up to 5% of adults worldwide, contributing to significant disease …