The protein homeostasis (proteostasis) system encompasses the cellular processes that
regulate protein synthesis, folding, concentration, trafficking and degradation. In the case of …

The proteostasis network and associated protein quality control (PQC) mechanisms ensure
proteome functionality and are essential for cell survival. A distinctive feature of eukaryotic …

The condition of having a healthy, functional proteome is known as protein homeostasis, or
proteostasis. Establishing and maintaining proteostasis is the province of the proteostasis …

A proteostasis network represents a sophisticated cellular system that controls the whole
process which leads to properly folded functional proteins. The imbalance of proteostasis …

During aging, animals experience a decline in proteostasis activity, including loss of stress-
response activation, culminating in the accumulation of misfolded proteins and toxic …

Imbalances in mitochondrial proteostasis are associated with pathologic mitochondrial
dysfunction implicated in etiologically diverse diseases. This has led to considerable interest …

Cellular functionality relies on a well-balanced, but highly dynamic proteome. Dysfunction of
mitochondrial protein import leads to the cytosolic accumulation of mitochondrial precursor …

Glucocerebrosidase (GCase) is implicated in both a rare, monogenic disorder (Gaucher
disease, GD) and a common, multifactorial condition (Parkinson's disease); hence, it is an …

The protein homeostasis network keeps proteins in their correct shapes and avoids
unwanted aggregation. In turn, the accumulation of aberrantly misfolded proteins has been …

Protein folding, quality control, maturation, and trafficking are essential processes for proper
cellular homeostasis. Around one-third of the human proteome is targeted to the …