The molecular principles of gene regulation by Polycomb repressive complexes
NP Blackledge, RJ Klose - Nature reviews Molecular cell biology, 2021 - nature.com
Precise control of gene expression is fundamental to cell function and development.
Although ultimately gene expression relies on DNA-binding transcription factors to guide the …
Although ultimately gene expression relies on DNA-binding transcription factors to guide the …
The roles of Polycomb repressive complexes in mammalian development and cancer
More than 80 years ago, the first Polycomb-related phenotype was identified in Drosophila
melanogaster. Later, a group of diverse genes collectively called Polycomb group (PcG) …
melanogaster. Later, a group of diverse genes collectively called Polycomb group (PcG) …
Molecular mechanisms directing PRC2 recruitment and H3K27 methylation
A Laugesen, JW Højfeldt, K Helin - Molecular cell, 2019 - cell.com
The polycomb repressive complex 2 (PRC2) is a chromatin-associated methyltransferase
catalyzing mono-, di-, and trimethylation of lysine 27 on histone H3 (H3K27). This activity is …
catalyzing mono-, di-, and trimethylation of lysine 27 on histone H3 (H3K27). This activity is …
Histone H2AK119 mono-ubiquitination is essential for polycomb-mediated transcriptional repression
Polycomb group proteins (PcGs) maintain transcriptional repression to preserve cellular
identity in two distinct repressive complexes, PRC1 and PRC2, that modify histones by …
identity in two distinct repressive complexes, PRC1 and PRC2, that modify histones by …
PRC1 catalytic activity is central to polycomb system function
The Polycomb repressive system is an essential chromatin-based regulator of gene
expression. Despite being extensively studied, how the Polycomb system selects its target …
expression. Despite being extensively studied, how the Polycomb system selects its target …
PRC2 is high maintenance
As the process that silences gene expression ensues during development, the stage is set
for the activity of Polycomb-repressive complex 2 (PRC2) to maintain these repressed gene …
for the activity of Polycomb-repressive complex 2 (PRC2) to maintain these repressed gene …
Synergy between variant PRC1 complexes defines polycomb-mediated gene repression
NA Fursova, NP Blackledge, M Nakayama, S Ito… - Molecular cell, 2019 - cell.com
The Polycomb system modifies chromatin and plays an essential role in repressing gene
expression to control normal mammalian development. However, the components and …
expression to control normal mammalian development. However, the components and …
The complexity of PRC2 subcomplexes
Polycomb repressive complex 2 (PRC2) is a multisubunit protein complex essential for the
development of multicellular organisms. Recruitment of PRC2 to target genes, followed by …
development of multicellular organisms. Recruitment of PRC2 to target genes, followed by …
PRC2. 1 and PRC2. 2 synergize to coordinate H3K27 trimethylation
Summary Polycomb repressive complex 2 (PRC2) is composed of EED, SUZ12, and EZH1/2
and mediates mono-, di-, and trimethylation of histone H3 at lysine 27. At least two …
and mediates mono-, di-, and trimethylation of histone H3 at lysine 27. At least two …
Polycomb gene silencing mechanisms: PRC2 chromatin targeting, H3K27me3'readout', and phase separation-based compaction
Modulation of chromatin structure and/or modification by Polycomb repressive complexes
(PRCs) provides an important means to partition the genome into functionally distinct …
(PRCs) provides an important means to partition the genome into functionally distinct …