In the past 15 years, B cells have been rediscovered to be not merely bystanders but rather
active participants in autoimmune aetiology. This has been fuelled in part by the clinical …

A link between oxidative stress and hypertension has been firmly established in multiple
animal models of hypertension but remains elusive in humans. While initial studies focused …

Cardiovascular disease is a leading cause of death and reduced quality of life, proven by
the latest data of the Global Burden of Disease Study, and is only gaining in prevalence …

The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …

Hypertension affects 30% of adults and is the leading risk factor for heart attack and stroke.
Traditionally, hypertension has been regarded as a disorder of two systems that are involved …

Crosstalk between the gut microbiota and the host has attracted considerable attention
owing to its involvement in diverse diseases. Chronic kidney disease (CKD) is commonly …

Cardiac injury remains a major cause of morbidity and mortality worldwide. Despite
significant advances, a full understanding of why the heart fails to fully recover function after …

Guzik and Touyz Oxidation and Inflammation in Vascular Aging 661 and endothelium. 22
Perivascular fibrosis is greatly dependent on immune cells because it is prevented in …

Elevated cardiovascular risk including stroke, heart failure, and heart attack is present even
after normalization of blood pressure in patients with hypertension. Underlying immune cell …

Adipose tissue (AT) dysfunction, characterized by loss of its homeostatic functions, is a
hallmark of non-communicable diseases. It is characterized by chronic low-grade …