Activity-based NIR fluorescent probes based on the versatile hemicyanine scaffold: design strategy, biomedical applications, and outlook

H Li, H Kim, F Xu, J Han, Q Yao, J Wang, K Pu… - Chemical Society …, 2022 - pubs.rsc.org
The discovery of a near-infrared (NIR, 650–900 nm) fluorescent chromophore hemicyanine
dye with high structural tailorability is of great significance in the field of detection …

Hemicyanine‐based near‐infrared activatable probes for imaging and diagnosis of diseases

Z Zeng, SS Liew, X Wei, K Pu - … Chemie International Edition, 2021 - Wiley Online Library
Molecular activatable probes with near‐infrared (NIR) fluorescence play a critical role in in
vivo imaging of biomarkers for drug screening and disease diagnosis. With structural …

Activity‐based NIR enzyme fluorescent probes for the diagnosis of tumors and image‐guided surgery

H Li, D Kim, Q Yao, H Ge, J Chung, J Fan… - Angewandte …, 2021 - Wiley Online Library
Near‐infrared (NIR) activatable fluorescent probes have been considered to be the effective
edge tools for the investigation of cell biology and disease diagnosis because of their …

Recent progresses in small-molecule enzymatic fluorescent probes for cancer imaging

HW Liu, L Chen, C Xu, Z Li, H Zhang… - Chemical Society …, 2018 - pubs.rsc.org
Abnormal enzymatic activities are directly related to the development of cancers. Identifying
the location and expression levels of these enzymes in live cancer cells have considerable …

Targeting gamma-glutamyl transpeptidase: A pleiotropic enzyme involved in glutathione metabolism and in the control of redox homeostasis

A Mitrić, I Castellano - Free Radical Biology and Medicine, 2023 - Elsevier
Gamma-glutamyl transpeptidase (GGT) is an enzyme located on the outer membrane of the
cells where it regulates the metabolism of glutathione (GSH), the most abundant intracellular …

Recognition moieties of small molecular fluorescent probes for bioimaging of enzymes

X Wu, W Shi, X Li, H Ma - Accounts of chemical research, 2019 - ACS Publications
Conspectus Enzymes are a class of important substances for life, and their abnormal levels
are associated with many diseases. Thus, great progress has been made in the past decade …

Self-immolative colorimetric, fluorescent and chemiluminescent chemosensors

J Yan, S Lee, A Zhang, J Yoon - Chemical Society Reviews, 2018 - pubs.rsc.org
Self-immolative chemistry features a cascade of disassembly reactions in response to
external stimuli, which provides great opportunities to design new self-immolative …

Near-infrared fluorescent probes for the detection of cancer-associated proteases

JI Scott, Q Deng, M Vendrell - ACS chemical biology, 2021 - ACS Publications
Proteases are enzymes capable of catalyzing protein breakdown, which is critical across
many biological processes. There are several families of proteases, each of which perform …

γ-glutamyltransferase-activatable fluoro-photoacoustic reporter for highly sensitive diagnosis of acute liver injury and tumor

Q Liu, J Yuan, R Jiang, L He, X Yang, L Yuan… - Analytical …, 2023 - ACS Publications
γ-Glutamyltransferase (GGT) has been recognized as an important clinical biomarker that is
closely related to many diseases. Visualizing the GGT fluctuation facilitates early disease …

Recent advances in the development of fluorescent probes for γ‐glutamyltranspeptidase

ZY Hu, XY Chen, YS Yang, SJ Wang, ZG Hu… - Coordination Chemistry …, 2024 - Elsevier
Abstract γ-Glutamyltranspeptidase (GGT) plays a significant role in the regulation of cellular
redox homeostasis and other physiological or pathophysiological processes. The over …