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Fibroblast and myofibroblast activation in normal tissue repair and fibrosis
The term 'fibroblast'often serves as a catch-all for a diverse array of mesenchymal cells,
including perivascular cells, stromal progenitor cells and bona fide fibroblasts. Although …
including perivascular cells, stromal progenitor cells and bona fide fibroblasts. Although …
Molecular and cellular mechanisms of liver fibrosis and its regression
Chronic liver injury leads to liver inflammation and fibrosis, through which activated
myofibroblasts in the liver secrete extracellular matrix proteins that generate the fibrous scar …
myofibroblasts in the liver secrete extracellular matrix proteins that generate the fibrous scar …
Myofibroblasts and fibrosis: mitochondrial and metabolic control of cellular differentiation
Cardiac fibrosis is mediated by the activation of resident cardiac fibroblasts, which
differentiate into myofibroblasts in response to injury or stress. Although myofibroblast …
differentiate into myofibroblasts in response to injury or stress. Although myofibroblast …
Hepatic stellate cells as key target in liver fibrosis
Progressive liver fibrosis, induced by chronic viral and metabolic disorders, leads to more
than one million deaths annually via development of cirrhosis, although no antifibrotic …
than one million deaths annually via development of cirrhosis, although no antifibrotic …
Liver fibrosis and repair: immune regulation of wound healing in a solid organ
Fibrosis is a highly conserved and co-ordinated protective response to tissue injury. The
interaction of multiple pathways, molecules and systems determines whether fibrosis is self …
interaction of multiple pathways, molecules and systems determines whether fibrosis is self …
[PDF][PDF] Hepatic stellate cells and liver fibrosis
Hepatic stellate cells are resident perisinusoidal cells distributed throughout the liver, with a
remarkable range of functions in normal and injured liver. Derived embryologically from …
remarkable range of functions in normal and injured liver. Derived embryologically from …
[HTML][HTML] Liver fibrosis: From basic science towards clinical progress, focusing on the central role of hepatic stellate cells
H Akkız, RK Gieseler, A Canbay - International Journal of Molecular …, 2024 - mdpi.com
The burden of chronic liver disease is globally increasing at an alarming rate. Chronic liver
injury leads to liver inflammation and fibrosis (LF) as critical determinants of long-term …
injury leads to liver inflammation and fibrosis (LF) as critical determinants of long-term …
Carcinoma-associated fibroblasts: orchestrating the composition of malignancy
P Gascard, TD Tlsty - Genes & development, 2016 - genesdev.cshlp.org
The tumor stroma is no longer seen solely as physical support for mutated epithelial cells but
as an important modulator and even a driver of tumorigenicity. Within the tumor stromal …
as an important modulator and even a driver of tumorigenicity. Within the tumor stromal …
Epigenetic regulation in fibrosis progress
T Xue, X Qiu, H Liu, C Gan, Z Tan, Y **e, Y Wang… - Pharmacological …, 2021 - Elsevier
Fibrosis, a common process of chronic inflammatory diseases, is defined as a repair
response disorder when organs undergo continuous damage, ultimately leading to scar …
response disorder when organs undergo continuous damage, ultimately leading to scar …
Molecular and tissue alterations of collagens in fibrosis
The collagen network is altered in fibrotic diseases associated with extracellular matrix
(ECM) biosynthesis and remodeling. This mini-review focuses on the quantitative and …
(ECM) biosynthesis and remodeling. This mini-review focuses on the quantitative and …