Myocardial fibrosis, the expansion of the cardiac interstitium through deposition of
extracellular matrix proteins, is a common pathophysiologic companion of many different …

TGF-β is extensively implicated in the pathogenesis of fibrosis. In fibrotic lesions, spatially
restricted generation of bioactive TGF-β from latent stores requires the cooperation of …

Cardiac fibrosis is a common pathophysiologic companion of most myocardial diseases,
and is associated with systolic and diastolic dysfunction, arrhythmogenesis, and adverse …

Innate immune cells play important roles in tissue injury and repair following acute
myocardial infarction (MI). Although reprogramming of macrophage metabolism has been …

The master cytokine TGF-β mediates tissue fibrosis associated with inflammation and tissue
injury. TGF-β induces fibroblast activation and differentiation into myofibroblasts that secrete …

Cardiac fibrosis is mediated by the activation of resident cardiac fibroblasts, which
differentiate into myofibroblasts in response to injury or stress. Although myofibroblast …

Fibrosis is a common pathology in cardiovascular disease. In the heart, fibrosis causes
mechanical and electrical dysfunction, and in the kidney, it predicts the onset of renal failure …

The adult mammalian heart contains abundant interstitial and perivascular fibroblasts that
expand following injury and play a reparative role but also contribute to maladaptive fibrotic …

Expansion and activation of fibroblasts following cardiac injury is important for repair but
may also contribute to fibrosis, remodeling, and dysfunction. The authors discuss the …

Cardiovascular diseases remain the leading cause of death worldwide, with pathological
fibrotic remodeling mediated by activated cardiac myofibroblasts representing a unifying …