The academic literature on and industrial practice of control of solution crystallization
processes have seen major advances in the past 15 years that have been enabled by …

Crystallization is the main separation and purification process for the manufacturing of drug
substances. Not only does crystallization affect the efficiency of downstream operations such …

This scientific paper presents an overview of continuous solution crystallization in the
pharmaceutical industry. Since the specific knowledge spectrum of precipitation is very …

In an industrial crystallization process, crystal shape strongly influences end-product quality
and functionality, as well as downstream processing. In addition, nucleation events, solvent …

Crystallization is a natural occurring process but also a process abundantly used in the
industry. Crystallization can occur from a solution, from the melt or via deposition of material …

Wet granulation is a very important unit operation that finds applications in many industries
mainly pharmaceutical and chemical industries. Various granulation technologies in batch …

A review of surface chemistry concepts is presented, with the principal objective of
identifying interfacial phenomena and surface chemistry interactions involved in gas hydrate …

In this paper, we present the application of four different in situ analytical techniques to
monitor the solvent-mediated polymorphic transformation of l-glutamic acid. Focused beam …

A key bottleneck in the production of pharmaceuticals and many other products is the
formation of crystals from solution. The control of the crystal size distribution can be critically …

Fluidized bed granulation is a widely applied wet granulation technique in the
pharmaceutical industry to produce solid dosage forms. The process involves the spraying …