Patterning of the cell cortex by Rho GTPases
Abstract The Rho GTPases—RHOA, RAC1 and CDC42—are small GTP binding proteins
that regulate basic biological processes such as cell locomotion, cell division and …
that regulate basic biological processes such as cell locomotion, cell division and …
Who's in control? Principles of Rab GTPase activation in endolysosomal membrane trafficking and beyond
The eukaryotic endomembrane system consists of multiple interconnected organelles. Rab
GTPases are organelle-specific markers that give identity to these membranes by recruiting …
GTPases are organelle-specific markers that give identity to these membranes by recruiting …
Rab GTPase function in endosome and lysosome biogenesis
Eukaryotic cells maintain a highly organized endolysosomal system. This system regulates
the protein and lipid content of the plasma membrane, it participates in the intracellular …
the protein and lipid content of the plasma membrane, it participates in the intracellular …
[HTML][HTML] Multiple roles of the small GTPase Rab7
Rab7 is a small GTPase that belongs to the Rab family and controls transport to late
endocytic compartments such as late endosomes and lysosomes. The mechanism of action …
endocytic compartments such as late endosomes and lysosomes. The mechanism of action …
Regulation of small gtpases by gefs, gaps, and gdis
J Cherfils, M Zeghouf - Physiological reviews, 2013 - journals.physiology.org
Small GTPases use GDP/GTP alternation to actuate a variety of functional switches that are
pivotal for cell dynamics. The GTPase switch is turned on by GEFs, which stimulate …
pivotal for cell dynamics. The GTPase switch is turned on by GEFs, which stimulate …
Rab proteins and the compartmentalization of the endosomal system
Of the approximately 70 human Rab GTPases, nearly three-quarters are involved in
endocytic trafficking. Significant plasticity in endosomal membrane transport pathways is …
endocytic trafficking. Significant plasticity in endosomal membrane transport pathways is …
The life cycle of phagosomes: formation, maturation, and resolution
Phagocytosis, the regulated uptake of large particles (> 0.5 μm in diameter), is essential for
tissue homeostasis and is also an early, critical component of the innate immune response …
tissue homeostasis and is also an early, critical component of the innate immune response …
Endosome maturation
Being deeply connected to signalling, cell dynamics, growth, regulation, and defence,
endocytic processes are linked to almost all aspects of cell life and disease. In this review …
endocytic processes are linked to almost all aspects of cell life and disease. In this review …
Role of Rab GTPases in membrane traffic and cell physiology
Intracellular membrane traffic defines a complex network of pathways that connects many of
the membrane-bound organelles of eukaryotic cells. Although each pathway is governed by …
the membrane-bound organelles of eukaryotic cells. Although each pathway is governed by …
Rab GTPases as coordinators of vesicle traffic
Membrane trafficking between organelles by vesiculotubular carriers is fundamental to the
existence of eukaryotic cells. Central in ensuring that cargoes are delivered to their correct …
existence of eukaryotic cells. Central in ensuring that cargoes are delivered to their correct …