[HTML][HTML] On a highway to the brain: A review on nose-to-brain drug delivery using nanoparticles

ML Formica, DA Real, ML Picchio, E Catlin… - Applied Materials …, 2022 - Elsevier
The administration of drugs to the central nervous system (CNS) is primarily controlled by
the blood-brain barrier (BBB), a structure that prevents the passage of foreign compounds …

Nanocrystals as a master key to deliver hydrophobic drugs via multiple administration routes

MB McGuckin, J Wang, R Ghanma, N Qin… - Journal of Controlled …, 2022 - Elsevier
The poor aqueous solubility of many approved drugs and most new chemical entities poses
a challenge to drug delivery scientists working in academic and industrial labs. Despite the …

Hydrogel-forming microarray patches with cyclodextrin drug reservoirs for long-acting delivery of poorly soluble cabotegravir sodium for HIV Pre-Exposure Prophylaxis

F Volpe-Zanutto, LK Vora, IA Tekko… - Journal of Controlled …, 2022 - Elsevier
Hydrogel-forming microarray patches (HF-MAPs) offer minimally invasive, pain-free and
prolonged drug delivery. These devices are designed to be self-administered and self …

Ring inserts as a useful strategy to prepare tip-loaded microneedles for long-acting drug delivery with application in HIV pre-exposure prophylaxis

AJ Paredes, AD Permana, F Volpe-Zanutto, MN Amir… - Materials & …, 2022 - Elsevier
The role of microneedle array patches (MAPs) and, in particular, dissolving MAPs in
transdermal drug delivery has increased exponentially over the last decade. MAPs are able …

Microneedle‐assisted transdermal delivery of nanoparticles: Recent insights and prospects

AJ Guillot, M Martínez‐Navarrete… - Wiley …, 2023 - Wiley Online Library
Transdermal delivery of drugs offers an interesting alternative for the administration of
molecules that present certain troubles when delivered by the oral route. It can produce …

[HTML][HTML] Intradermal delivery of the antiretroviral drugs cabotegravir and rilpivirine by dissolving microarray patches: Investigation of lymphatic uptake

IK Ramöller, F Volpe-Zanutto, LK Vora… - Journal of Controlled …, 2024 - Elsevier
The lymphatic system possesses the main viral replication sites in the body following viral
infection. Unfortunately, current antiretroviral agents penetrate the lymph nodes insufficiently …

[HTML][HTML] Bioadhesive eutectogels supporting drug nanocrystals for long-acting delivery to mucosal tissues

MB Bianchi, C Zhang, E Catlin, G Sandri, M Calderón… - Materials Today Bio, 2022 - Elsevier
Eutectogels (Egels) are an emerging class of soft ionic materials outperforming traditional
temperature-intolerant hydrogels and costly ionogels. Due to their excellent elasticity, non …

Application of multipolymers system in the development of hydrogel-forming microneedle integrated with polyethylene glycol reservoir for transdermal delivery of …

U Mahfufah, NAF Sultan, AMN Fitri, D Elim… - European Polymer …, 2023 - Elsevier
Parasitic infection is one of the health problems that cause many deaths in develo**
countries. One of the infectious parasites that is a problem for the world community is cystic …

Polymeric microarray patches for enhanced transdermal delivery of the poorly soluble drug olanzapine

PE McKenna, MTA Abbate, LK Vora… - … Applied Materials & …, 2023 - ACS Publications
Transdermal drug delivery is an alternative route of administration that offers avoidance of
the associated drawbacks of orally and parenterally administered hydrophobics. However …

[HTML][HTML] Systemic delivery of tenofovir alafenamide using dissolving and implantable microneedle patches

AJ Paredes, F Volpe-Zanutto, LK Vora, IA Tekko… - Materials Today Bio, 2022 - Elsevier
The human immunodeficiency virus (HIV) remains a global health concern, with 37.7 million
people currently living with the infection and 1.5 million new cases every year. Current …