The immune system in Cushing's syndrome

V Hasenmajer, E Sbardella, F Sciarra… - Trends in endocrinology …, 2020 - cell.com
Cushing's syndrome (CS), or chronic hypercortisolism, induces a variety of alterations in the
immune system, often leading to severe clinical complications such as sepsis and …

Diurnal cortisol rhythm as a predictor of breast cancer survival

SE Sephton, RM Sapolsky, HC Kraemer… - Journal of the …, 2000 - academic.oup.com
Background: Abnormal circadian rhythms have been observed in patients with cancer, but
the prognostic value of such alterations has not been confirmed. We examined the …

Neuropsychiatric findings in Cushing syndrome and exogenous glucocorticoid administration

MN Starkman - Endocrinology and Metabolism Clinics, 2013 - endo.theclinics.com
Cushing disease (CD), the major type of spontaneous Cushing syndrome (SCS), is the
classic endocrine disease characterized by hypersecretion of cortisol and diminished …

Epidemiologic evaluation of postoperative wound infection in clean‐contaminated wounds: a retrospective study of 239 dogs and cats

M Nicholson, M Beal, F Shofer, DC Brown - Veterinary surgery, 2002 - Wiley Online Library
Objective—To evaluate risk factors for development of postoperative wound infections in
clean‐contaminated wounds. Study Design—Retrospective clinical study. Sample …

Molecular drivers of potential immunotherapy failure in adrenocortical carcinoma

C Fiorentini, S Grisanti, D Cosentini, A Abate… - Journal of …, 2019 - Wiley Online Library
Adrenocortical carcinoma (ACC) is a rare, highly aggressive cancer, often insensitive to
conventional chemotherapeutics agents. Early diagnosis, followed by radical surgical …

Immunotherapy in adrenocortical carcinoma: predictors of response, efficacy, safety, and mechanisms of resistance

M Araujo-Castro, E Pascual-Corrales, J Molina-Cerrillo… - Biomedicines, 2021 - mdpi.com
Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with limited treatment
options in the advanced stages. Immunotherapy offers hope for altering the orthodox …

The immunosuppressive effects of chronic morphine treatment are partially dependent on corticosterone and mediated by the μ-opioid receptor

J Wang, R Charboneau… - Journal of leukocyte …, 2002 - academic.oup.com
Wild-type and μ-opioid receptor knockout (MORKO) mice were used to investigate the role of
corticosterone (CORT) and the μ-opioid receptor (MOR) in chronic morphine-mediated …

Overt immune dysfunction after Cushing's syndrome remission: a consecutive case series and review of the literature

F da Mota, C Murray, S Ezzat - The Journal of Clinical …, 2011 - academic.oup.com
Context: Autoimmune diseases frequently improve during active Cushing's syndrome.
Several studies have reported new onset or exacerbation of these conditions upon cortisol …

Circadian clock disruption impairs immune oscillation in chronic endogenous hypercortisolism: a multi-level analysis from a multicentre clinical trial

V Hasenmajer, E Sbardella, F Sciarra, C Simeoli… - Ebiomedicine, 2024 - thelancet.com
Background Glucocorticoids (GC) are potent entrainers of the circadian clock. However, their
effects on biological rhythms in chronic human exposure have yet to be studied …

Comprehensive characterization of the regulatory landscape of adrenocortical carcinoma: Novel transcription factors and targets associated with prognosis

JCD Muzzi, JM Magno, JS Souza, LM Alvarenga… - Cancers, 2022 - mdpi.com
Simple Summary Adult adrenocortical carcinoma (ACC) is a rare and aggressive tumor in
adults, usually associated with excessive steroid secretion. It is highly metastatic and has …