Parasites are designed by evolution to invade the host and survive in its organism until they
are ready to reproduce. Parasites release a variety of molecules that help them to penetrate …

Choline kinase (CK) catalyzes the first phosphorylation reaction in the CDP-choline pathway
for the biosynthesis of phosphatidylcholine (PC), yielding phosphocholine (P-Cho) from …

Previously, we demonstrated that helminth-infected MS patients showed significantly lower
number of relapses, reduced disability scores, and lower MRI activity compared to …

There is increasing awareness that helminth infections can ameliorate proinflammatory
conditions. In part, this is due to their inherent ability to induce Th2 and, perhaps, regulatory …

Atopic allergy is characterized by an increase in IgE antibodies that signal through the high-
affinity Fcε receptor (FcεRI) to induce the release of inflammatory mediators from mast cells …

Relatively little is known about the filarial proteins that interact with the human host. Although
the filarial genome has recently been completed, protein profiles have been limited to only a …

Understanding modulation of the host immune system by pathogens offers rich therapeutic
potential. Parasitic filarial nematodes are often tolerated in human hosts for decades with …

T‐helper 2 (Th2) cell responses play a critical role in protection against helminth infections.
In the case of Schistosoma mansoni, an important helminth parasite of man, data from a …

The intimate association between maternal and placental tissues elicits an interesting
immunological paradox. Placental tissue contains paternal antigens, but under normal …

The transcription factor Rora has been shown to be important for the development of ILC2
and the regulation of ILC3, macrophages and Treg cells. Here we investigate the role of …