Cell migration is essential for physiological processes as diverse as development, immune
defence and wound healing. It is also a hallmark of cancer malignancy. Thousands of …

The cytoskeleton and its components—actin, microtubules and intermediate filaments—
have been studied for decades, and multiple roles of the individual cytoskeletal …

INTRODUCTION Our textbook understanding of the nanoscale organization of the cell and
its relationship to the thousands of proteins that drive cellular metabolism comes largely from …

Actin plays roles in many important cellular processes, including cell motility, organelle
movement, and cell signaling. The discovery of transmembrane actin-binding proteins at the …

Granule cells (GCs) are the most numerous cell type in the cerebellum and indeed, in the
brain: at least 99% of all cerebellar neurons are granule cells. In this review article, we first …

Nuclear migration is critical for the proper positioning of neurons in the develo** brain. It is
known that bidirectional microtubule motors are required for nuclear transport, yet the …

Vertebrate brain development depends on a complex program of cell proliferation and
migration. Post-mitotic neuronal migration in the develo** cerebral cortex involves …

Cells store excess energy in the form of lipid droplets (LDs), a specialized sub-compartment
of the endoplasmic reticulum (ER) network. The lipodystrophy protein seipin is a key player …

In neurons, the endoplasmic reticulum (ER) forms a highly dynamic network that enters
axons and presynaptic terminals and plays a central role in Ca2+ homeostasis and synapse …

Detachment of newborn neurons from the neuroepithelium is required for correct neuronal
architecture and functional circuitry. This process, also known as delamination, involves …