Mechanistic understanding the bioeffects of ultrasound-driven microbubbles to enhance macromolecule delivery
P Qin, T Han, CH Alfred, L Xu - Journal of controlled release, 2018 - Elsevier
Ultrasound-driven microbubbles can trigger reversible membrane perforation
(sonoporation), open interendothelial junctions and stimulate endocytosis, thereby providing …
(sonoporation), open interendothelial junctions and stimulate endocytosis, thereby providing …
Sonoporation: mechanistic insights and ongoing challenges for gene transfer
Microbubbles first developed as ultrasound contrast agents have been used to assist
ultrasound for cellular drug and gene delivery. Their oscillation behavior during ultrasound …
ultrasound for cellular drug and gene delivery. Their oscillation behavior during ultrasound …
[HTML][HTML] A human clinical trial using ultrasound and microbubbles to enhance gemcitabine treatment of inoperable pancreatic cancer
Background The primary aim of our study was to evaluate the safety and potential toxicity of
gemcitabine combined with microbubbles under sonication in inoperable pancreatic cancer …
gemcitabine combined with microbubbles under sonication in inoperable pancreatic cancer …
Ultrasound and microbubble mediated drug delivery: acoustic pressure as determinant for uptake via membrane pores or endocytosis
I De Cock, E Zagato, K Braeckmans, Y Luan… - Journal of controlled …, 2015 - Elsevier
Although promising results are achieved in ultrasound mediated drug delivery, its underlying
biophysical mechanisms remain to be elucidated. Pore formation as well as endocytosis has …
biophysical mechanisms remain to be elucidated. Pore formation as well as endocytosis has …
Ultrasound microrobots with reinforcement learning
M Schrage, M Medany, D Ahmed - Advanced Materials …, 2023 - Wiley Online Library
Ultrasound is an attractive modality for controlling micro/nanorobots due to penetrating deep
into tissue, not being affected by the opaque nature of animal bodies, and generating a …
into tissue, not being affected by the opaque nature of animal bodies, and generating a …
[HTML][HTML] Contrast-enhanced and targeted ultrasound
Ultrasonic imaging is becoming the most popular medical imaging modality, owing to the
low price per examination and its safety. However, blood is a poor scatterer of ultrasound …
low price per examination and its safety. However, blood is a poor scatterer of ultrasound …
The promising shadow of microbubble over medical sciences: from fighting wide scope of prevalence disease to cancer eradication
Abstract Microbubbles are typically 0.5–10 μm in size. Their size tends to make it easier for
medication delivery mechanisms to navigate the body by allowing them to be swallowed …
medication delivery mechanisms to navigate the body by allowing them to be swallowed …
Sonoporation using nanoparticle-loaded microbubbles increases cellular uptake of nanoparticles compared to co-incubation of nanoparticles and microbubbles
S Snipstad, S Hanstad, A Bjørkøy, Ý Mørch… - Pharmaceutics, 2021 - mdpi.com
Therapeutic agents can benefit from encapsulation in nanoparticles, due to improved
pharmacokinetics and biodistribution, protection from degradation, increased cellular uptake …
pharmacokinetics and biodistribution, protection from degradation, increased cellular uptake …
Biological active matter aggregates: Inspiration for smart colloidal materials
Aggregations of social organisms exhibit a remarkable range of properties and
functionalities. Multiple examples, such as fire ants or slime mold, show how a population of …
functionalities. Multiple examples, such as fire ants or slime mold, show how a population of …
Targeted ultrasound contrast agents for ultrasound molecular imaging and therapy
Ultrasound contrast agents (UCAs) are used routinely in the clinic to enhance contrast in
ultrasonography. More recently, UCAs have been functionalised by conjugating ligands to …
ultrasonography. More recently, UCAs have been functionalised by conjugating ligands to …