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Osteoarthritis pathogenesis: a review of molecular mechanisms
Osteoarthritis (OA), the most prevalent chronic joint disease, increases in prevalence with
age, and affects majority of individuals over the age of 65 and is a leading musculoskeletal …
age, and affects majority of individuals over the age of 65 and is a leading musculoskeletal …
Cartilage damage in osteoarthritis and rheumatoid arthritis—two unequal siblings
T Pap, A Korb-Pap - Nature Reviews Rheumatology, 2015 - nature.com
Cartilage damage is a key feature of degenerative joint disorders—primarily osteoarthritis
(OA)—and chronic inflammatory joint diseases, such as rheumatoid arthritis (RA) …
(OA)—and chronic inflammatory joint diseases, such as rheumatoid arthritis (RA) …
Engineering exosomes derived from subcutaneous fat MSCs specially promote cartilage repair as miR-199a-3p delivery vehicles in Osteoarthritis
S Zhao, G **u, J Wang, Y Wen, J Lu, B Wu… - Journal of …, 2023 - Springer
Osteoarthritis (OA) is a degenerative joint disease involving cartilage. Exosomes derived
from Mesenchymal stem cells (MSCs) therapy improves articular cartilage repair, but …
from Mesenchymal stem cells (MSCs) therapy improves articular cartilage repair, but …
MMP13 is a critical target gene during the progression of osteoarthritis
Introduction Osteoarthritis (OA) is a degenerative joint disease affecting a large population of
people. The mechanism of this highly prevalent disease is not fully understood. Currently …
people. The mechanism of this highly prevalent disease is not fully understood. Currently …
Inflammation and epigenetic regulation in osteoarthritis
Osteoarthritis (OA) was once defined as a non-inflammatory arthropathy, but it is now well-
recognized that there is a major inflammatory component to this disease. In addition to …
recognized that there is a major inflammatory component to this disease. In addition to …
[HTML][HTML] Cartilage and bone destruction in arthritis: pathogenesis and treatment strategy: a literature review
D Tateiwa, H Yoshikawa, T Kaito - Cells, 2019 - mdpi.com
Arthritis is inflammation of the joints accompanied by osteochondral destruction. It can take
many forms, including osteoarthritis, rheumatoid arthritis, and psoriatic arthritis. These …
many forms, including osteoarthritis, rheumatoid arthritis, and psoriatic arthritis. These …
TGF-β signaling and the development of osteoarthritis
Osteoarthritis (OA) is a common joint degenerative disease affecting the whole joint
structure, including articular cartilage, subchondral bone and synovial tissue. Although …
structure, including articular cartilage, subchondral bone and synovial tissue. Although …
Multifunctional compounds: Smart molecules for multifactorial diseases
Multifunctional compounds (MFCs) are designed broadly as hybrid or conjugated drugs or
as chimeric drugs from two or more pharmacophores/drugs having specific pharmacological …
as chimeric drugs from two or more pharmacophores/drugs having specific pharmacological …
Targeting TGFβ signaling in subchondral bone and articular cartilage homeostasis
Osteoarthritis (OA) is the most common degenerative joint disease and no disease-
modifying therapy for OA is currently available. Targeting articular cartilage alone may not …
modifying therapy for OA is currently available. Targeting articular cartilage alone may not …
Biologic basis of osteoarthritis: state of the evidence
CJ Malemud - Current opinion in rheumatology, 2015 - journals.lww.com
Human osteoarthritis is a systemic musculoskeletal disorder involving activation of innate
and adaptive immune systems accompanied by inflammation exemplified by the elevated …
and adaptive immune systems accompanied by inflammation exemplified by the elevated …