Imaging brain microstructure with diffusion MRI: practicality and applications

DC Alexander, TB Dyrby, M Nilsson… - NMR in …, 2019 - Wiley Online Library
This article gives an overview of microstructure imaging of the brain with diffusion MRI and
reviews the state of the art. The microstructure‐imaging paradigm aims to estimate and map …

[HTML][HTML] Connectome 2.0: Develo** the next-generation ultra-high gradient strength human MRI scanner for bridging studies of the micro-, meso-and macro …

SY Huang, T Witzel, B Keil, A Scholz, M Davids, P Dietz… - NeuroImage, 2021 - Elsevier
The first phase of the Human Connectome Project pioneered advances in MRI technology
for map** the macroscopic structural connections of the living human brain through the …

Microstructural imaging of the human brain with a 'super-scanner': 10 key advantages of ultra-strong gradients for diffusion MRI

DK Jones, DC Alexander, R Bowtell, M Cercignani… - NeuroImage, 2018 - Elsevier
The key component of a microstructural diffusion MRI 'super-scanner'is a dedicated high-
strength gradient system that enables stronger diffusion weightings per unit time compared …

Noninvasive quantification of solid tumor microstructure using VERDICT MRI

E Panagiotaki, S Walker-Samuel, B Siow… - Cancer …, 2014 - aacrjournals.org
There is a need for biomarkers that are useful for noninvasive imaging of tumor
pathophysiology and drug efficacy. Through its use of endogenous water, diffusion-weighted …

Conventions and nomenclature for double diffusion encoding NMR and MRI

N Shemesh, SN Jespersen… - Magnetic resonance …, 2016 - Wiley Online Library
Stejskal and Tanner's ingenious pulsed field gradient design from 1965 has made diffusion
NMR and MRI the mainstay of most studies seeking to resolve microstructural information in …

Diffusion-weighted imaging in cancer: physical foundations and applications of restriction spectrum imaging

NS White, CR McDonald, N Farid, J Kuperman… - Cancer …, 2014 - aacrjournals.org
Diffusion-weighted imaging (DWI) has been at the forefront of cancer imaging since the early
2000s. Before its application in clinical oncology, this powerful technique had already …

[HTML][HTML] The link between diffusion MRI and tumor heterogeneity: Map** cell eccentricity and density by diffusional variance decomposition (DIVIDE)

F Szczepankiewicz, D van Westen, E Englund… - Neuroimage, 2016 - Elsevier
The structural heterogeneity of tumor tissue can be probed by diffusion MRI (dMRI) in terms
of the variance of apparent diffusivities within a voxel. However, the link between the …

Microstructural characterization of normal and malignant human prostate tissue with vascular, extracellular, and restricted diffusion for cytometry in tumours magnetic …

E Panagiotaki, RW Chan, N Dikaios… - Investigative …, 2015 - journals.lww.com
Objective The aim of this study was to demonstrate the feasibility of the recently introduced
Vascular, Extracellular, and Restricted Diffusion for Cytometry in Tumours (VERDICT) …

Time-dependent diffusion MRI in cancer: tissue modeling and applications

O Reynaud - Frontiers in Physics, 2017 - frontiersin.org
In diffusion weighted imaging (DWI), the apparent diffusion coefficient (ADC) has been
recognized as a useful and sensitive surrogate for cell density, paving the way for non …

[HTML][HTML] The sensitivity of diffusion MRI to microstructural properties and experimental factors

M Afzali, T Pieciak, S Newman, E Garyfallidis… - Journal of Neuroscience …, 2021 - Elsevier
Diffusion MRI is a non-invasive technique to study brain microstructure. Differences in the
microstructural properties of tissue, including size and anisotropy, can be represented in the …