The large number of ion channels found in all nervous systems poses fundamental
questions concerning how the characteristic intrinsic properties of single neurons are …

The action potential of the squid giant axon is formed by just two voltage-dependent
conductances in the cell membrane, yet mammalian central neurons typically express more …

Neurons in most animals live a very long time relative to the half-lives of all of the proteins
that govern excitability and synaptic transmission. Consequently, homeostatic mechanisms …

Abstract Analysis of presynaptic determinants of synaptic strength has been difficult at
cortical synapses, mainly due to the lack of direct access to presynaptic elements. Here we …

Potassium channels are particularly important in determining the shape and duration of the
action potential, controlling the membrane potential, modulating hormone secretion …

Neuronal membrane excitability must be resilient to perturbations that can take place over
timescales from milliseconds to months (or even years in long-lived animals). A great deal of …

The role of large-conductance Ca2+-dependent K+ channels (BK-channels; also known as
maxi-K-or slo-channels) in spike broadening during repetitive firing was studied in CA1 …

The voltage-gated potassium (Kv) channel subunit Kv1. 1 is a major constituent of
presynaptic A-type channels that modulate synaptic transmission in CNS neurons. Here, we …

The dynamic clamp uses computer simulation to introduce artificial membrane or synaptic
conductances into biological neurons and to create hybrid circuits of real and model …

Kv3 channels are thought to be essential for the fast-spiking (FS) phenotype in GABAergic
interneurons, but how these channels confer the ability to generate action potentials (APs) at …