In the era of personalized medicine and targeted therapies for the management of patients
with cancer, ultrasensitive detection methods for tumor genoty**, such as next-generation …

Liquid biopsies, in particular, analysis of cell-free DNA, are expected to revolutionize the
current landscape of cancer diagnostics and treatment. However, the existing methods for …

Abstract Background Diffuse Midline Glioma (DMG) with the H3K27M mutation is a lethal
childhood brain cancer, with patients rarely surviving 2 years from diagnosis. Methods We …

Background Brain tumor surgery must balance the benefit of maximal resection against the
risk of inflicting severe damage. The impact of increased resection is diagnosis-specific …

Abstract Diffuse Intrinsic Pontine Glioma (DIPG), now known as Diffuse Midline Glioma
(DMG) is a devastating pediatric brain tumor with limited treatment options and a very poor …

Classification of gliomas involves the combination of histological features with molecular
biomarkers to establish an integrated histomolecular diagnosis. Here, we report on the …

Abstract Introduction Diffuse midline gliomas (DMGs) are infiltrative midline gliomas
harboring H3K27M mutations and are generally associated with poor outcomes. H3K27M …

Diffuse midline glioma (DMG) is the leading cause of brain tumor-related deaths in children.
DMG typically presents with variable neurologic symptoms between ages 3 and 10 …

Since the development of Sanger sequencing in 1977, sequencing technology has played a
pivotal role in molecular biology research by enabling the interpretation of biological genetic …

Abstract Introduction H3 K27M-mutated diffuse midline gliomas (H3-DMGs) are aggressive
tumors with a fatal outcome. This study integrating individual patient data (IPD) from …