As much as the cellular viability is important for the living organisms, the elimination of
unnecessary or damaged cells has the opposite necessity for the maintenance of …

Evasion of apoptosis is one of the crucial acquired capabilities used by cancer cells to fend
off anticancer therapies. Inhibitor of apoptosis (IAP) proteins exert a range of biological …

Beneath the complexity and idiopathy of every cancer lies a limited number of'mission
critical'events that have propelled the tumour cell and its progeny into uncontrolled …

Every cell in a multicellular organism has the potential to die by apoptosis, but tumour cells
often have faulty apoptotic pathways. These defects not only increase tumour mass, but also …

Upon massive DNA damage cells fail to undergo productive DNA repair and trigger the cell
death response. Resistance to cell death is linked to cellular transformation and …

Survivin, as a member of the inhibitor of apoptosis proteins (IAPs) family, acts as a
suppressor of apoptosis and plays a central role in cell division. Survivin has been …

The'inhibitor of apoptosis'(IAP) gene family, which was discovered less than a decade ago,
encodes a group of structurally related proteins that, in addition to their ability to suppress …

Evasion of apoptosis is considered to be one of the hallmarks of human cancers. This cell
death modality is executed by caspases and several upstream regulatory factors, which …

IFNs are a family of cytokines with pleiotropic biological effects mediated by scores of
responsive genes. IFNs were the first human proteins to be effective in cancer therapy and …

One of the hallmarks of human cancers is the intrinsic or acquired resistance to apoptosis.
Evasion of apoptosis may contribute to carcinogenesis, tumor progression and also to …