Ageing, cellular senescence and neurodegenerative disease

M Kritsilis, S V. Rizou, PN Koutsoudaki… - International journal of …, 2018 - mdpi.com
Ageing is a major risk factor for develo** many neurodegenerative diseases. Cellular
senescence is a homeostatic biological process that has a key role in driving ageing. There …

Cellular senescence in neurodegenerative diseases

C Martínez-Cué, N Rueda - Frontiers in cellular neuroscience, 2020 - frontiersin.org
Cellular senescence is a homeostatic biological process characterized by a permanent state
of cell cycle arrest that can contribute to the decline of the regenerative potential and …

Caffeine and Parkinson's disease: multiple benefits and emerging mechanisms

X Ren, JF Chen - Frontiers in Neuroscience, 2020 - frontiersin.org
Parkinson's disease (PD) is the second most common neurodegenerative disorder,
characterized by dopaminergic neurodegeneration, motor impairment and non-motor …

Alpha‐Synuclein in Parkinson's Disease: From Pathogenetic Dysfunction to Potential Clinical Application

L Xu, J Pu - Parkinson's disease, 2016 - Wiley Online Library
Parkinson's disease is a neurodegenerative disease/synucleinopathy that develops slowly;
however, there is no efficient method of early diagnosis, nor is there a cure. Progressive …

[HTML][HTML] Targeting autophagy using small-molecule compounds to improve potential therapy of Parkinson's disease

K Zhang, S Zhu, J Li, T Jiang, L Feng, J Pei… - … Pharmaceutica Sinica B, 2021 - Elsevier
Abstract Parkinson's disease (PD), known as one of the most universal neurodegenerative
diseases, is a serious threat to the health of the elderly. The current treatment has been …

Novel approaches for the treatment of Alzheimer's and Parkinson's disease

M Van Bulck, A Sierra-Magro, J Alarcon-Gil… - International journal of …, 2019 - mdpi.com
Neurodegenerative disorders affect around one billion people worldwide. They can arise
from a combination of genomic, epigenomic, metabolic, and environmental factors. Aging is …

[HTML][HTML] Exosomes derived from miR-188-3p-modified adipose-derived mesenchymal stem cells protect Parkinson's disease

Q Li, Z Wang, H **ng, Y Wang, Y Guo - Molecular Therapy-Nucleic Acids, 2021 - cell.com
Parkinson's disease (PD) is the second-most common neurodegenerative disease after
Alzheimer's disease. The most important pathological feature of PD is the irreversible …

Autophagy and ubiquitin-proteasome system

Y Wang, WD Le - Autophagy: biology and diseases: basic science, 2019 - Springer
Millions of protein molecules are synthesized per minute in each cell, and simultaneously,
millions of protein molecules are degraded. Mutated and misfolded newly synthesized …

ncRNAs and their impact on dopaminergic neurons: autophagy pathways in Parkinson's disease

R Thapa, E Moglad, M Afzal, G Gupta, AA Bhat… - Ageing Research …, 2024 - Elsevier
Parkinson's Disease (PD) is a complex neurological illness that causes severe motor and
non-motor symptoms due to a gradual loss of dopaminergic neurons in the substantia nigra …

Extracellular vesicles, the emerging mirrors of brain physiopathology

A Cano, M Ettcheto, M Bernuz, R Puerta… - … journal of biological …, 2023 - pmc.ncbi.nlm.nih.gov
Extracellular vesicles are secreted by a wide variety of cells, and their primary functions
include intercellular communication, immune responses, human reproduction, and synaptic …