MAPK-activated protein kinases: servant or partner?

N Ronkina, M Gaestel - Annual review of biochemistry, 2022 - annualreviews.org
Mitogen-activated protein kinase (MAPK)-activated protein kinases (MAPKAPKs) are
defined by their exclusive activation by MAPKs. They can be activated by classical and …

Interleukin 33 is a guardian of barriers and a local alarmin

NT Martin, MU Martin - Nature immunology, 2016 - nature.com
Abstract Interleukin 33 (IL-33) is a member of the IL-1 family of cytokines with a growing
number of target cells and a plethora of biological functions. Although it has commonalities …

Piezo1 channels restrain ILC2s and regulate the development of airway hyperreactivity

BP Hurrell, S Shen, X Li, Y Sakano… - Journal of Experimental …, 2024 - rupress.org
Mechanosensitive ion channels sense force and pressure in immune cells to drive the
inflammatory response in highly mechanical organs. Here, we report that Piezo1 channels …

A network map of IL-33 signaling pathway

SM Pinto, Y Subbannayya, DAB Rex, R Raju… - Journal of cell …, 2018 - Springer
Abstract Interleukin-33 (IL-33) is a member of the IL-1 family of cytokines that play a central
role in the regulation of immune responses. Its release from epithelial and endothelial cells …

Conflicting vascular and metabolic impact of the IL-33/sST2 axis

R Altara, R Ghali, Z Mallat, A Cataliotti… - Cardiovascular …, 2018 - academic.oup.com
Abstract Interleukin 33 (IL-33), which is expressed by several immune cell types, endothelial
and epithelial cells, and fibroblasts, is a cytokine of the IL-1 family that acts both intra-and …

The contrasting role of extracellular vesicles in vascular inflammation and tissue repair

S Oggero, S Austin-Williams, LV Norling - Frontiers in Pharmacology, 2019 - frontiersin.org
Extracellular vesicles are a heterogeneous family of vesicles, generated from different
subcellular compartments and released into the extracellular space. Composed of a lipid …

Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations

M Daya, N Rafaels, TM Brunetti, S Chavan… - Nature …, 2019 - nature.com
Asthma is a complex disease with striking disparities across racial and ethnic groups.
Despite its relatively high burden, representation of individuals of African ancestry in asthma …

[HTML][HTML] Dual immune regulatory roles of interleukin-33 in pathological conditions

H Guo, EA Bossila, X Ma, C Zhao, Y Zhao - Cells, 2022 - mdpi.com
Interleukin-33 (IL-33), a member of the IL-1 cytokine family and a multifunctional cytokine,
plays critical roles in maintaining host homeostasis and in pathological conditions, such as …

Pleiotropic Effects of IL-33 on CD4+ T Cell Differentiation and Effector Functions

F Alvarez, JH Fritz, CA Piccirillo - Frontiers in immunology, 2019 - frontiersin.org
IL-33, a member of the IL-1 family of cytokines, was originally described in 2005 as a
promoter of type 2 immune responses. However, recent evidence reveals a more complex …

Peptide correlation analysis (PeCorA) reveals differential proteoform regulation

M Dermit, TM Peters-Clarke, E Shishkova… - Journal of proteome …, 2020 - ACS Publications
Shotgun proteomics techniques infer the presence and quantity of proteins using peptide
proxies produced by cleavage of the proteome with a protease. Most protein quantitation …