Ever since the brain was identified as an insulin-sensitive organ, evidence has rapidly
accumulated that insulin action in the brain produces multiple behavioral and metabolic …

Genetic predisposition to obesity presents a paradox: how do genetic variants with a
detrimental impact on human health persist through evolutionary time? Numerous …

FTO, the first RNA demethylase discovered, mediates the demethylation of internal N 6-
methyladenosine (m 6 A) and N 6, 2-O-dimethyladenosine (m 6 A m) at the+ 1 position from …

Introduction We examined whether obesity at ages 50, 60, and 70 years is associated with
subsequent dementia. Changes in body mass index (BMI) for more than 28 years before …

Abstract N 6-methyladenosine (m6A) is a reversible modification in mRNA and has been
shown to regulate processing, translation and decay of mRNA. However, the roles of m6A …

Normal aging and Alzheimer's disease (AD) cause profound changes in the brain's structure
and function. AD in particular is accompanied by widespread cortical neuronal loss, and loss …

Fat mass and obesity-associated gene (FTO) is a member of the Fe (II)-and oxoglutarate-
dependent AlkB dioxygenase family and is linked to both obesity and intellectual disability …

Dopaminergic (DA) signaling governs the control of complex behaviors, and its deregulation
has been implicated in a wide range of diseases. Here we demonstrate that inactivation of …

There is a growing realization that early life influences have lasting impact on brain function
and structure. Recent research has demonstrated that genetic relationships in adults can be …

Neuroimaging is becoming increasingly common in obesity research as investigators try to
understand the neurological underpinnings of appetite and body weight in humans. Positron …