Electrophysiological characterization of live human tissue from epilepsy patients has been
performed for many decades. Although initially these studies sought to understand the …

Activation of γ-aminobutyric acid (GABA A) receptors have been associated with the onset of
epileptiform events. To investigate if a causal relationship exists between GABA A receptor …

In the human neocortex coherent interlaminar theta oscillations are driven by deep cortical
layers, suggesting neurons in these layers exhibit distinct electrophysiological properties. To …

Epilepsy is a complex disorder involving neurological alterations that lead to the
pathological development of spontaneous, recurrent seizures. For decades, seizures were …

Electrophysiological oscillations are thought to create temporal windows of communication
between brain regions. We show here that human cortical slices maintained in vitro can …

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Objective Epilepsy is one of the most common neurological disorders. Many individuals
continue to have seizures despite medical and surgical treatments, suggesting adjunctive …

Background Whole-cell patch-clamp electrophysiology is an essential technique for
understanding how single neurons translate their diverse inputs into a functional output. The …

Drug‐resistant focal epilepsy (DRFE), defined by failure of two antiepileptic drugs, affects
30% of epileptic patients. Epilepsy surgeries are alternative options for this population …