Complexes of β-lactam antibiotics and their Schiff-base derivatives as a weapon in the fight against bacterial resistance
M Zabiszak, J Frymark, K Ogawa, M Skrobańska… - Coordination Chemistry …, 2023 - Elsevier
Abstract β-lactam antibiotics are widely used chemical compounds in medicine due to their
strong antibacterial activity. These drugs are produced by fungi (Penicillium …
strong antibacterial activity. These drugs are produced by fungi (Penicillium …
Bacterial Metallostasis: Metal Sensing, Metalloproteome Remodeling, and Metal Trafficking
Transition metals function as structural and catalytic cofactors for a large diversity of proteins
and enzymes that collectively comprise the metalloproteome. Metallostasis considers all …
and enzymes that collectively comprise the metalloproteome. Metallostasis considers all …
Metalation of extracytoplasmic proteins and bacterial cell envelope homeostasis
Cell physiology requires innumerable metalloenzymes supported by the selective import of
metal ions. Within the crowded cytosol, most enzymes acquire their cognate cofactors from a …
metal ions. Within the crowded cytosol, most enzymes acquire their cognate cofactors from a …
Metallo-β-lactamases and a tug-of-war for the available zinc at the host–pathogen interface
Abstract Metallo-β-lactamases (MBLs) are zinc-dependent hydrolases that inactivate
virtually all β-lactam antibiotics. The expression of MBLs by Gram-negative bacteria severely …
virtually all β-lactam antibiotics. The expression of MBLs by Gram-negative bacteria severely …
A conserved zinc-binding site in Acinetobacter baumannii PBP2 required for elongasome-directed bacterial cell shape
Acinetobacter baumannii is a gram-negative bacterial pathogen that causes challenging
nosocomial infections. β-lactam targeting of penicillin-binding protein (PBP)–mediated cell …
nosocomial infections. β-lactam targeting of penicillin-binding protein (PBP)–mediated cell …
Metalloenzyme mimicry and modulation strategies to conquer antimicrobial resistance: Metal-ligand coordination perspectives
The incessant resistivity of pathogenic microbes to antibiotics continuously constitutes a
major threat to human wellness, thus, searching for effective therapeutic approaches …
major threat to human wellness, thus, searching for effective therapeutic approaches …
[HTML][HTML] The development of New Delhi metallo-β-lactamase-1 inhibitors since 2018
X Gu, M Zheng, L Chen, H Li - Microbiological Research, 2022 - Elsevier
New Delhi metallo-β-lactamase-1 (NDM-1) can hydrolyze almost all antibiotics of the β-
lactam group, resulting in the generation of multidrug resistant bacteria. Besides its broad …
lactam group, resulting in the generation of multidrug resistant bacteria. Besides its broad …
Targeting bacterial nickel transport with aspergillomarasmine A suppresses virulence-associated Ni-dependent enzymes
Microbial Ni2+ homeostasis underpins the virulence of several clinical pathogens. Ni2+ is
an essential cofactor in urease and [NiFe]-hydrogenases involved in colonization and …
an essential cofactor in urease and [NiFe]-hydrogenases involved in colonization and …
Drug development concerning metallo-β-lactamases in gram-negative bacteria
X Li, J Zhao, B Zhang, X Duan, J Jiao, W Wu… - Frontiers in …, 2022 - frontiersin.org
β-Lactams have been a clinical focus since their emergence and indeed act as a powerful
tool to combat severe bacterial infections, but their effectiveness is threatened by drug …
tool to combat severe bacterial infections, but their effectiveness is threatened by drug …
Worldwide trend discovery of structural and functional relationship of metallo-β-lactamase for structure-based drug design: a bibliometric evaluation and patent …
Abstract Metallo-β-lactamase (MBL) is an enzyme produced by clinically important bacteria
that can inactivate many commonly used antibiotics, making them a significant concern in …
that can inactivate many commonly used antibiotics, making them a significant concern in …