According to the widely accepted" three Es" model, the host immune system eliminates
malignant cell precursors and contains microscopic neoplasms in a dynamic equilibrium …

Over the past decade, it has become clear that the stimulator of interferon genes (STING)
pathway is critical for a variety of immune responses. This endoplasmic reticulum-anchored …

DNA replication is remarkably accurate with estimates of only a handful of mutations per
human genome per cell division cycle. Replication stress caused by DNA lesions …

Summary G-quadruplexes (G4s) form throughout the genome and influence important
cellular processes. Their deregulation can challenge DNA replication fork progression and …

Background While small extracellular vesicles (sEVs)-derived circular RNAs (circRNAs)
have been emerged as significant players in cancer, the function and underlying mechanism …

Small cell lung cancer (SCLC) is a recalcitrant cancer characterized by high frequency loss-
of-function mutations in tumor suppressors with a lack of targeted therapy due to absence of …

Deciphering mechanisms for cancer immune escape may provide targets for improving
immunotherapy efficacy. By in vivo genome-wide CRISPR loss-of-function screening in a …

Ovarian cancer remains a leading cause of death among gynecological cancers, largely due
to its propensity for peritoneal metastasis and the development of drug resistance. This …

Melanoma, recognized as the most aggressive type of skin cancer, has experienced a
notable increase in cases, especially within populations with fair skin. This highly aggressive …

Background: Gliomas, the most prevalent type of primary brain tumor, stand out as one of the
most aggressive and lethal types of human cancer. Methods & Results: To uncover potential …