Crystal engineering of pharmaceutical cocrystals in the discovery and development of improved drugs

G Bolla, B Sarma, AK Nangia - Chemical reviews, 2022 - ACS Publications
The subject of crystal engineering started in the 1970s with the study of topochemical
reactions in the solid state. A broad chemical definition of crystal engineering was published …

[HTML][HTML] Pharmaceutical cocrystals: A review of preparations, physicochemical properties and applications

M Guo, X Sun, J Chen, T Cai - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Pharmaceutical cocrystals are multicomponent systems in which at least one component is
an active pharmaceutical ingredient and the others are pharmaceutically acceptable …

Structural analysis of molecular materials using the pair distribution function

MW Terban, SJL Billinge - Chemical Reviews, 2021 - ACS Publications
This is a review of atomic pair distribution function (PDF) analysis as applied to the study of
molecular materials. The PDF method is a powerful approach to study short-and …

A chemical perspective on the clinical use of platinum-based anticancer drugs

S Alassadi, MJ Pisani, NJ Wheate - Dalton Transactions, 2022 - pubs.rsc.org
Platinum drugs have been a mainstay of cancer chemotherapy since the introduction of
cisplatin in the 1970s. Since then, carboplatin and oxaliplatin have been approved world …

Pillararene-based variable stoichiometry co-crystallization: A versatile approach to diversified solid-state superstructures

M Li, Y Liu, L Shao, B Hua, M Wang… - Journal of the …, 2022 - ACS Publications
Variable stoichiometry co-crystals are important in solid-state supramolecular chemistry as
they allow studies of structure–property relationships while permitting the synthesis of new …

[HTML][HTML] Co-amorphous drug formulations in numbers: Recent advances in co-amorphous drug formulations with focus on co-formability, molar ratio, preparation …

J Liu, H Grohganz, K Löbmann, T Rades, NJ Hempel - Pharmaceutics, 2021 - mdpi.com
Co-amorphous drug delivery systems (CAMS) are characterized by the combination of two
or more (initially crystalline) low molecular weight components that form a homogeneous …

Mechanochemical and mechanoenzymatic synthesis of pharmacologically active compounds: A green perspective

M Pérez-Venegas, E Juaristi - ACS Sustainable Chemistry & …, 2020 - ACS Publications
Recently, the application of mechanochemical strategies in organic synthesis has attracted
the attention of both the academic and industrial chemical communities. The high efficiency …

[HTML][HTML] Mechanochemistry: A green approach in the preparation of pharmaceutical cocrystals

M Solares-Briones, G Coyote-Dotor, JC Páez-Franco… - Pharmaceutics, 2021 - mdpi.com
Mechanochemistry is considered an alternative attractive greener approach to prepare
diverse molecular compounds and has become an important synthetic tool in different fields …

Investigating the function and design of molecular materials through terahertz vibrational spectroscopy

PA Banks, EM Kleist, MT Ruggiero - Nature Reviews Chemistry, 2023 - nature.com
Terahertz spectroscopy has proved to be an essential tool for the study of condensed phase
materials. Terahertz spectroscopy probes the low-frequency vibrational dynamics of atoms …

Cocrystal engineering of pharmaceutical solids: Therapeutic potential and challenges

SN Wong, YCS Chen, B Xuan, CC Sun, SF Chow - CrystEngComm, 2021 - pubs.rsc.org
Cocrystals are an emerging class of crystalline materials composed of two or more different
molecules in the same crystal lattice that are physically connected by non-ionic and non …