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Crystal engineering of pharmaceutical cocrystals in the discovery and development of improved drugs
The subject of crystal engineering started in the 1970s with the study of topochemical
reactions in the solid state. A broad chemical definition of crystal engineering was published …
reactions in the solid state. A broad chemical definition of crystal engineering was published …
[HTML][HTML] Pharmaceutical cocrystals: A review of preparations, physicochemical properties and applications
M Guo, X Sun, J Chen, T Cai - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Pharmaceutical cocrystals are multicomponent systems in which at least one component is
an active pharmaceutical ingredient and the others are pharmaceutically acceptable …
an active pharmaceutical ingredient and the others are pharmaceutically acceptable …
Structural analysis of molecular materials using the pair distribution function
This is a review of atomic pair distribution function (PDF) analysis as applied to the study of
molecular materials. The PDF method is a powerful approach to study short-and …
molecular materials. The PDF method is a powerful approach to study short-and …
A chemical perspective on the clinical use of platinum-based anticancer drugs
S Alassadi, MJ Pisani, NJ Wheate - Dalton Transactions, 2022 - pubs.rsc.org
Platinum drugs have been a mainstay of cancer chemotherapy since the introduction of
cisplatin in the 1970s. Since then, carboplatin and oxaliplatin have been approved world …
cisplatin in the 1970s. Since then, carboplatin and oxaliplatin have been approved world …
Pillararene-based variable stoichiometry co-crystallization: A versatile approach to diversified solid-state superstructures
Variable stoichiometry co-crystals are important in solid-state supramolecular chemistry as
they allow studies of structure–property relationships while permitting the synthesis of new …
they allow studies of structure–property relationships while permitting the synthesis of new …
[HTML][HTML] Co-amorphous drug formulations in numbers: Recent advances in co-amorphous drug formulations with focus on co-formability, molar ratio, preparation …
Co-amorphous drug delivery systems (CAMS) are characterized by the combination of two
or more (initially crystalline) low molecular weight components that form a homogeneous …
or more (initially crystalline) low molecular weight components that form a homogeneous …
Mechanochemical and mechanoenzymatic synthesis of pharmacologically active compounds: A green perspective
Recently, the application of mechanochemical strategies in organic synthesis has attracted
the attention of both the academic and industrial chemical communities. The high efficiency …
the attention of both the academic and industrial chemical communities. The high efficiency …
[HTML][HTML] Mechanochemistry: A green approach in the preparation of pharmaceutical cocrystals
M Solares-Briones, G Coyote-Dotor, JC Páez-Franco… - Pharmaceutics, 2021 - mdpi.com
Mechanochemistry is considered an alternative attractive greener approach to prepare
diverse molecular compounds and has become an important synthetic tool in different fields …
diverse molecular compounds and has become an important synthetic tool in different fields …
Investigating the function and design of molecular materials through terahertz vibrational spectroscopy
Terahertz spectroscopy has proved to be an essential tool for the study of condensed phase
materials. Terahertz spectroscopy probes the low-frequency vibrational dynamics of atoms …
materials. Terahertz spectroscopy probes the low-frequency vibrational dynamics of atoms …
Cocrystal engineering of pharmaceutical solids: Therapeutic potential and challenges
Cocrystals are an emerging class of crystalline materials composed of two or more different
molecules in the same crystal lattice that are physically connected by non-ionic and non …
molecules in the same crystal lattice that are physically connected by non-ionic and non …