Principles governing the phase separation of multidomain proteins
A variety of membraneless organelles, often termed “biological condensates”, play an
important role in the regulation of cellular processes such as gene transcription, translation …
important role in the regulation of cellular processes such as gene transcription, translation …
Conformational ensembles of intrinsically disordered proteins and flexible multidomain proteins
FE Thomasen, K Lindorff-Larsen - Biochemical Society …, 2022 - portlandpress.com
Intrinsically disordered proteins (IDPs) and multidomain proteins with flexible linkers show a
high level of structural heterogeneity and are best described by ensembles consisting of …
high level of structural heterogeneity and are best described by ensembles consisting of …
Physics-driven coarse-grained model for biomolecular phase separation with near-quantitative accuracy
Various physics-and data-driven sequence-dependent protein coarse-grained models have
been developed to study biomolecular phase separation and elucidate the dominant …
been developed to study biomolecular phase separation and elucidate the dominant …
Accurate model of liquid–liquid phase behavior of intrinsically disordered proteins from optimization of single-chain properties
Many intrinsically disordered proteins (IDPs) may undergo liquid–liquid phase separation
(LLPS) and participate in the formation of membraneless organelles in the cell, thereby …
(LLPS) and participate in the formation of membraneless organelles in the cell, thereby …
A synergy between site-specific and transient interactions drives the phase separation of a disordered, low-complexity domain
TAR DNA-binding protein 43 (TDP-43) is involved in key processes in RNA metabolism and
is frequently implicated in many neurodegenerative diseases, including amyotrophic lateral …
is frequently implicated in many neurodegenerative diseases, including amyotrophic lateral …
Improved predictions of phase behaviour of intrinsically disordered proteins by tuning the interaction range
G Tesei, K Lindorff-Larsen - Open Research Europe, 2023 - pmc.ncbi.nlm.nih.gov
The formation and viscoelastic properties of condensates of intrinsically disordered proteins
(IDPs) is dictated by amino acid sequence and solution conditions. Because of the …
(IDPs) is dictated by amino acid sequence and solution conditions. Because of the …
Expanding the molecular language of protein liquid–liquid phase separation
Understanding the relationship between a polypeptide sequence and its phase separation
has important implications for analysing cellular function, treating disease and designing …
has important implications for analysing cellular function, treating disease and designing …
Sequence-dependent material properties of biomolecular condensates and their relation to dilute phase conformations
D Sundaravadivelu Devarajan, J Wang… - Nature …, 2024 - nature.com
Material properties of phase-separated biomolecular condensates, enriched with disordered
proteins, dictate many cellular functions. Contrary to the progress made in understanding the …
proteins, dictate many cellular functions. Contrary to the progress made in understanding the …
Design of intrinsically disordered protein variants with diverse structural properties
Intrinsically disordered proteins (IDPs) perform a broad range of functions in biology,
suggesting that the ability to design IDPs could help expand the repertoire of proteins with …
suggesting that the ability to design IDPs could help expand the repertoire of proteins with …
Direct prediction of intrinsically disordered protein conformational properties from sequence
Intrinsically disordered regions (IDRs) are ubiquitous across all domains of life and play a
range of functional roles. While folded domains are generally well-described by a stable 3D …
range of functional roles. While folded domains are generally well-described by a stable 3D …