Procreation is essential for survival of species. Not surprisingly, complex neuronal networks
have evolved to mediate the diverse internal and external environmental inputs that regulate …

Metastasis is a major cause of death in cancer patients and involves a multistep process
including detachment of cancer cells from a primary cancer, invasion of surrounding tissue …

Background Puberty, a complex biologic process involving sexual development, accelerated
linear growth, and adrenal maturation, is initiated when gonadotropin-releasing hormone …

Natural peptides displaying agonist activity on the orphan G protein-coupled receptor
GPR54 were isolated from human placenta. These 54-, 14,-and 13-amino acid peptides …

We have recently described a molecular gatekeeper of the hypothalamic-pituitary-gonadal
axis with the observation that G protein-coupled receptor 54 (GPR54) is required in mice …

GPR54 is a G-protein-coupled receptor that displays a high percentage of identity in the
transmembrane domains with the galanin receptors. The ligand for GPR54 has been …

IN THE LATE 1980s and early 1990s, the elucidation of the molecular basis of acute
promyelocytic leukemia (APL) emerged as a paradigm for the connection between the …

Metastin is a novel peptide that has been isolated from the human placenta as the cognate
ligand of the G-protein-coupled receptor OT7T175 (or GPR54). However, its physiological …

The Kiss1 gene encodes a family of peptides called kisspeptins, which bind to the G protein-
coupled receptor GPR54. Kisspeptin (s) and its receptor are expressed in the forebrain, and …

Identification, in late 2003, of inactivating mutations of the G protein-coupled receptor
GPR54 as causative factor for absence of puberty and hypogonadotropic hypogonadism in …