The extended granin family: structure, function, and biomedical implications
The chromogranins (chromogranin A and chromogranin B), secretogranins (secretogranin II
and secretogranin III), and additional related proteins (7B2, NESP55, proSAAS, and VGF) …
and secretogranin III), and additional related proteins (7B2, NESP55, proSAAS, and VGF) …
Role of catestatin in the cardiovascular system and metabolic disorders
E Zalewska, P Kmieć, K Sworczak - Frontiers in cardiovascular …, 2022 - frontiersin.org
Catestatin is a multifunctional peptide that is involved in the regulation of the cardiovascular
and immune systems as well as metabolic homeostatis. It mitigates detrimental, excessive …
and immune systems as well as metabolic homeostatis. It mitigates detrimental, excessive …
Chromogranin A is an autoantigen in type 1 diabetes
Autoreactive CD4+ T cells are involved in the pathogenesis of many autoimmune diseases,
but the antigens that stimulate their responses have been difficult to identify and in most …
but the antigens that stimulate their responses have been difficult to identify and in most …
Chromogranin A and its fragments in cardiovascular, immunometabolic, and cancer regulation
Chromogranin A (CgA)—the index member of the chromogranin/secretogranin secretory
protein family—is ubiquitously distributed in endocrine, neuroendocrine, and immune cells …
protein family—is ubiquitously distributed in endocrine, neuroendocrine, and immune cells …
Dense-core secretory granule biogenesis
T Kim, MC Gondré-Lewis, I Arnaoutova… - Physiology, 2006 - journals.physiology.org
The dense-core secretory granule is a key organelle for secretion of hormones and
neuropeptides in endocrine cells and neurons, in response to stimulation. Cholesterol and …
neuropeptides in endocrine cells and neurons, in response to stimulation. Cholesterol and …
CAPS-1 and CAPS-2 are essential synaptic vesicle priming proteins
WJ Jockusch, D Speidel, A Sigler, JB Sørensen… - Cell, 2007 - cell.com
Before transmitter-filled synaptic vesicles can fuse with the plasma membrane upon
stimulation they have to be primed to fusion competence. The regulation of this priming …
stimulation they have to be primed to fusion competence. The regulation of this priming …
Biological function and clinical relevance of chromogranin A and derived peptides
MA D'amico, B Ghinassi, P Izzicupo… - Endocrine …, 2014 - ec.bioscientifica.com
Chromogranin A (CgA (CHGA)) is the major soluble protein co-stored and co-released with
catecholamines and can function as a pro-hormone by giving rise to several bioactive …
catecholamines and can function as a pro-hormone by giving rise to several bioactive …
Catestatin as a biomarker of cardiovascular diseases: a clinical perspective
Accounting for almost one-third of the global mortality, cardiovascular diseases (CVDs)
represent a major global health issue. Emerging data suggest that most of the well …
represent a major global health issue. Emerging data suggest that most of the well …
The antihypertensive chromogranin a peptide catestatin acts as a novel endocrine/paracrine modulator of cardiac inotropism and lusitropism
T Angelone, AM Quintieri, BK Brar… - …, 2008 - academic.oup.com
Circulating levels of catestatin (Cts; human chromogranin A352–372) decrease in the
plasma of patients with essential hypertension. Genetic ablation of the chromogranin A …
plasma of patients with essential hypertension. Genetic ablation of the chromogranin A …
Evidence that the CAG repeat in the androgen receptor gene is associated with the age-related decline in serum androgen levels in men
K Krithivas, SM Yurgalevitch, BA Mohr… - Journal of …, 1999 - joe.bioscientifica.com
The presence of activin A and its effects have previously been documented in the adrenal
gland, particularly in the human fetal adrenal gland and the rat adrenal gland. The primary …
gland, particularly in the human fetal adrenal gland and the rat adrenal gland. The primary …