The development of mature blood cells from haematopoietic stem cells has long served as a
model for stem-cell research, with the haematopoietic differentiation tree being widely used …

Developmental progression is driven by specific spatiotemporal domains of gene
expression, which give rise to stereotypically patterned embryos even in the presence of …

Transcription factors are adaptor molecules that detect regulatory sequences in the DNA
and target the assembly of protein complexes that control gene expression. Yet much of the …

ABSTRACT RUNX transcription factors orchestrate many different aspects of biology,
including basic cellular and developmental processes, stem cell biology and tumorigenesis …

The interaction of regulatory proteins with the complex nucleoprotein structures that are
found in mammalian cells involves chromatin reorganization at multiple levels. Mechanisms …

Metazoan development involves the successive activation and silencing of specific gene
expression programs and is driven by tissue-specific transcription factors programming the …

The Runx family of transcription factors (Runx1, Runx2, and Runx3) are highly conserved
and encode proteins involved in a variety of cell lineages, including blood and blood-related …

RUNX1 is a transcription factor that regulates critical processes in many aspects of
hematopoiesis. RUNX1 is also integral in defining the definitive hematopoietic stem cell. In …

Mutations in the additional sex comb-like 1 (ASXL1) gene were recently shown in various
myeloid malignancies, but they have not been comprehensively investigated in acute …

In humans, embryonic, fetal, and adult hemoglobins are sequentially expressed in
develo** erythroblasts during ontogeny. For the past 40 years, this process has been the …