Cellular senescence in the aging retina and developments of senotherapies for age-related macular degeneration
Age-related macular degeneration (AMD), a degenerative disease in the central macula
area of the neuroretina and the supporting retinal pigment epithelium, is the most common …
area of the neuroretina and the supporting retinal pigment epithelium, is the most common …
[HTML][HTML] VEGFR1 signaling in retinal angiogenesis and microinflammation
Five vascular endothelial growth factor receptor (VEGFR) ligands (VEGF-A,-B,–C,-D, and
placental growth factor [PlGF]) constitute the VEGF family. VEGF-A binds VEGF receptors 1 …
placental growth factor [PlGF]) constitute the VEGF family. VEGF-A binds VEGF receptors 1 …
Targeting myeloid derived suppressor cells reverts immune suppression and sensitizes BRAF-mutant papillary thyroid cancer to MAPK inhibitors
P Zhang, H Guan, S Yuan, H Cheng, J Zheng… - Nature …, 2022 - nature.com
MAPK signaling inhibitor (MAPKi) therapies show limited efficacy for advanced thyroid
cancers despite constitutive activation of the signaling correlates with disease recurrence …
cancers despite constitutive activation of the signaling correlates with disease recurrence …
Natural killer cells promote neutrophil extracellular traps and restrain macular degeneration in mice
X Dong, Y Song, Y Liu, X Kou, T Yang, SX Shi… - Science Translational …, 2024 - science.org
Neovascular age-related macular degeneration (nvAMD) is the leading cause of blindness
in the elderly population. Although it is known that nvAMD is associated with focal …
in the elderly population. Although it is known that nvAMD is associated with focal …
Wnt Signaling in vascular eye diseases
The Wnt signaling pathway plays a pivotal role in vascular morphogenesis in various organs
including the eye. Wnt ligands and receptors are key regulators of ocular angiogenesis both …
including the eye. Wnt ligands and receptors are key regulators of ocular angiogenesis both …
[HTML][HTML] Animal models of ocular angiogenesis: from development to pathologies
Pathological angiogenesis in the eye is an important feature in the pathophysiology of many
vision-threatening diseases, including retinopathy of prematurity, diabetic retinopathy, and …
vision-threatening diseases, including retinopathy of prematurity, diabetic retinopathy, and …
[WITHDRAWN] retinal vasculature in development and diseases
This article was withdrawn on October 15, 2020, at the request of the journal editors, with
agreement from the authors, owing to a substantial amount of unattributed or improperly …
agreement from the authors, owing to a substantial amount of unattributed or improperly …
Langerhans cells are essential components of the angiogenic niche during murine skin repair
Angiogenesis, the growth of new blood vessels from pre-existing vessels, occurs during
development, injury repair, and tumorigenesis to deliver oxygen, immune cells, and nutrients …
development, injury repair, and tumorigenesis to deliver oxygen, immune cells, and nutrients …
Multimodal single-cell/nucleus RNA sequencing data analysis uncovers molecular networks between disease-associated microglia and astrocytes with implications …
Because disease-associated microglia (DAM) and disease-associated astrocytes (DAA) are
involved in the pathophysiology of Alzheimer's disease (AD), we systematically identified …
involved in the pathophysiology of Alzheimer's disease (AD), we systematically identified …
Ocular vascular diseases: from retinal immune privilege to inflammation
The eye is an immune privileged tissue that insulates the visual system from local and
systemic immune provocation to preserve homeostatic functions of highly specialized retinal …
systemic immune provocation to preserve homeostatic functions of highly specialized retinal …