Protein methylation, a post-translational modification (PTM), is observed in a wide variety of
cell types from prokaryotes to eukaryotes. With recent and rapid advancements in epigenetic …

Arginine methylation is an influential post-translational modification occurring on histones,
RNA binding proteins, and many other cellular proteins, affecting their function by altering …

Numerous substrates have been identified for Type I and II arginine methyltransferases
(PRMTs). However, the full substrate spectrum of the only type III PRMT, PRMT7, and its …

In response to DNA damage, cells have developed a sophisticated signaling pathway,
consisting of DNA damage sensors, transducers, and effectors, to ensure efficient and …

Abstract LIM kinase 1 (LIMK1) is a member of the LIMK family that has been considered to
be involved in chemoresistance in various tumors, and N 6-methyladenosine (m 6 A) is the …

Protein arginine methyltransferases (PRMTs) regulate diverse biological processes and are
increasingly being recognized for their potential as drug targets. Here we report the …

Protein arginine methyltransferases (PRMTs) are found in a wide variety of eukaryotic
organisms and can regulate gene expression, DNA repair, RNA splicing, and stem cell …

The assembly of stress granules (SGs) is a well-known cellular strategy for reducing stress-
related damage and promoting cell survival. SGs have become important players in human …

Protein arginine methyltransferase (PRMT) enzymes play a crucial role in RNA splicing,
DNA damage repair, cell signaling, and differentiation. Arginine methylation is a prominent …

Despite the success of immune checkpoint inhibitor (ICI) therapy for cancer, resistance and
relapse are frequent. Combination therapies are expected to enhance response rates and …