Urothelial carcinoma of the bladder comprises two long-recognized disease entities with
distinct molecular features and clinical outcome. Low-grade non-muscle-invasive tumours …

Downregulated expression of anti-tumor miR-383 has been found in many kinds of cancer.
MiR-383 family members can directly target the 3′-untranslated region (3′-UTR) of the …

Tumor-associated macrophages (TAMs) are a major component of the tumor
microenvironment and have been shown to contribute to tumor aggressiveness. However …

Sorafenib is the unique recommended molecular-targeted drug for advanced hepatocellular
carcinoma, but its clinical use is limited due to cardiotoxicity. As sorafenib is an efficient …

The serine synthesis pathway (SSP) involving metabolic enzymes phosphoglycerate
dehydrogenase (PHGDH), phosphoserine aminotransferase 1 (PSAT1), and phosphoserine …

methylguanosine (m7G) modification is recently found to conservatively exist in RNA internal
position besides mRNA caps and mediates the various RNA metabolisms. As the core …

Numerous environmental, physiological, and pathological insults disrupt protein-folding
homeostasis in the endoplasmic reticulum (ER), referred to as ER stress. Eukaryotic cells …

Background Dysregulation of the common stress responsive transcription factor ATF3 has
been causally linked to many important human diseases such as cancer, atherosclerosis …

Chronic infection, such as Helicobacter pylori infection, has been associated with the
development of gastric cancer (GC). Pathogen-associated molecular patterns can trigger …

Glioblastoma and gliomas can have a wide range of histopathologic subtypes. These
heterogeneous histologic phenotypes originate from tumor cells with the distinct functions of …