Prostate cancer (CaP) remains the second leading cause of cancer deaths in western men.
CaP mortality results from diverse molecular mechanisms that mediate resistance to the …

Dysregulation of pre-mRNA splicing is a common hallmark of cancer cells and it is
associated with altered expression, localization, and mutations of the components of the …

Background Glioblastoma is one of the most devastating and incurable cancers due to its
aggressive behaviour and lack of available therapies, being its overall-survival from …

Glioblastomas remain the deadliest brain tumour, with a dismal∼ 12–16-month survival
from diagnosis. Therefore, identification of new diagnostic, prognostic and therapeutic tools …

Hepatocellular carcinoma (HCC) pathogenesis is associated with alterations in splicing
machinery components (spliceosome and splicing factors) and aberrant expression of …

Simple Summary Prostate cancer is a malignancy that affects a high number of men all over
the world. When indolent, prostate cancer can remain silent for years without needing …

Despite novel therapeutic strategies, advanced-stage prostate cancer (PCa) remains highly
lethal, pointing out the urgent need for effective therapeutic strategies. While dysregulation …

Background Glioblastoma is one of the most devastating cancer worldwide based on its
locally aggressive behavior and because it cannot be cured by current therapies. Defects in …

Metabolic dysregulation is prominent in triple-negative breast cancer (TNBC), yet
therapeutic strategies targeting cancer metabolism are limited. Here, utilizing multiomics …

Alternative splicing is an important source of heterogeneity underlying gene expression
between individual cells but remains an understudied area due to the paucity of …