Functions of ROS in macrophages and antimicrobial immunity
M Herb, M Schramm - Antioxidants, 2021 - mdpi.com
Reactive oxygen species (ROS) are a chemically defined group of reactive molecules
derived from molecular oxygen. ROS are involved in a plethora of processes in cells in all …
derived from molecular oxygen. ROS are involved in a plethora of processes in cells in all …
Angiotensin II signal transduction: an update on mechanisms of physiology and pathophysiology
The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …
The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology
For a long time, superoxide generation by an NADPH oxidase was considered as an oddity
only found in professional phagocytes. Over the last years, six homologs of the cytochrome …
only found in professional phagocytes. Over the last years, six homologs of the cytochrome …
NADPH oxidases and oxidase crosstalk in cardiovascular diseases: novel therapeutic targets
Y Zhang, P Murugesan, K Huang, H Cai - Nature Reviews Cardiology, 2020 - nature.com
Reactive oxygen species (ROS)-dependent production of ROS underlies sustained
oxidative stress, which has been implicated in the pathogenesis of cardiovascular diseases …
oxidative stress, which has been implicated in the pathogenesis of cardiovascular diseases …
Reactive oxygen species: from health to disease
Upon reaction with electrons, oxygen is transformed into reactive oxygen species (ROS). It
has long been known that ROS can destroy bacteria and destroy human cells, but research …
has long been known that ROS can destroy bacteria and destroy human cells, but research …
Sources of vascular nitric oxide and reactive oxygen species and their regulation
Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …
Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets
NADPH oxidases are a family of enzymes that generate reactive oxygen species (ROS). The
NOX1 (NADPH oxidase 1) and NOX2 oxidases are the major sources of ROS in the artery …
NOX1 (NADPH oxidase 1) and NOX2 oxidases are the major sources of ROS in the artery …
Biochemistry, physiology, and pathophysiology of NADPH oxidases in the cardiovascular system
atherosclerosis, hypertension, cardiac hypertrophy and remodeling, angiogenesis and
collateral formation, stroke, and heart failure. In this review, we discuss in detail the …
collateral formation, stroke, and heart failure. In this review, we discuss in detail the …
Nox proteins in signal transduction
The NADPH oxidase (Nox) family of superoxide (O2−) and hydrogen peroxide (H2O2)-
producing proteins has emerged as an important source of reactive oxygen species (ROS) …
producing proteins has emerged as an important source of reactive oxygen species (ROS) …
Evolution of NADPH oxidase inhibitors: selectivity and mechanisms for target engagement
S Altenhöfer, KA Radermacher… - Antioxidants & redox …, 2015 - liebertpub.com
Significance: Oxidative stress, an excess of reactive oxygen species (ROS) production
versus consumption, may be involved in the pathogenesis of different diseases. The only …
versus consumption, may be involved in the pathogenesis of different diseases. The only …