Cancer and Alzheimer's disease (AD) are characterized by (i) opposing biological
mechanisms,(ii) an inverse correlation between their incidences, and (iii) oxidative stress …

Colorectal cancer (CRC) is one of the costliest health problems and ranks second in cancer-
related mortality in developed countries. With the aid of proteomics, many protein …

Pancreatic cancer (PC) is difficult to defeat due to mechanism (s) driving metastasis and
drug resistance. Cancer stemness is a major challenging phenomenon associated with PC …

Colorectal cancer (CRC) is one of the leading causes of cancer-related death. Despite
advances in treatment, drug resistance remains a critical impediment. Post-translational …

Abstract Sulfiredoxin 1 (SRXN1) is a pivotal regulator of the antioxidant response in
eukaryotic cells. However, the role of SRXN1 in hepatocellular carcinoma (HCC) is far from …

Reactive oxygen species (ROS) are normal products of a number of biochemical reactions
and are important signaling molecules. However, at the same time, they are toxic to cells …

Background Lung cancer is the leading cause of cancer-related mortality worldwide.
Although cigarette smoking is an established risk factor for lung cancer, few reliable smoking …

Hepatology Publish Ahead of Print DOI:10.1097/HEP.0000000000001133 Page 1 The de-sulfinylation
enzyme sulfiredoxin-1 attenuates hepatic stellate cell activation and liver fibrosis by …

Aerobic glycolysis is a pivotal hallmark of cancers, including colorectal cancer. Evidence
shows glycolytic enzymes are regulated by post-translational modifications (PTMs), thereby …

The antioxidant protein sulfiredoxin-1 (SRX) is an oncogenic factor that promotes tumor
progression, but the regulatory mechanism underlying SRX degradation remains to be …