An introduction to the endogenous cannabinoid system

HC Lu, K Mackie - Biological psychiatry, 2016 - Elsevier
The endocannabinoid system (ECS) is a widespread neuromodulatory system that plays
important roles in central nervous system development, synaptic plasticity, and the response …

Endocannabinoid signalling in reward and addiction

LH Parsons, YL Hurd - Nature Reviews Neuroscience, 2015 - nature.com
Brain endocannabinoid (eCB) signalling influences the motivation for natural rewards (such
as palatable food, sexual activity and social interaction) and modulates the rewarding effects …

Modulation of striatal projection systems by dopamine

CR Gerfen, DJ Surmeier - Annual review of neuroscience, 2011 - annualreviews.org
The basal ganglia are a chain of subcortical nuclei that facilitate action selection. Two striatal
projection systems—so-called direct and indirect pathways—form the functional backbone of …

[HTML][HTML] Cannabis and its secondary metabolites: Their use as therapeutic drugs, toxicological aspects, and analytical determination

J Gonçalves, T Rosado, S Soares, AY Simão… - Medicines, 2019 - mdpi.com
Although the medicinal properties of Cannabis species have been known for centuries, the
interest on its main active secondary metabolites as therapeutic alternatives for several …

The adolescent brain and age-related behavioral manifestations

LP Spear - Neuroscience & biobehavioral reviews, 2000 - Elsevier
To successfully negotiate the developmental transition between youth and adulthood,
adolescents must maneuver this often stressful period while acquiring skills necessary for …

Phosphatidylserine in the brain: metabolism and function

HY Kim, BX Huang, AA Spector - Progress in lipid research, 2014 - Elsevier
Phosphatidylserine (PS) is the major anionic phospholipid class particularly enriched in the
inner leaflet of the plasma membrane in neural tissues. PS is synthesized from …

International Union of Pharmacology. XXVII. Classification of cannabinoid receptors

AC Howlett, F Barth, TI Bonner, G Cabral… - Pharmacological …, 2002 - Elsevier
Two types of cannabinoid receptor have been discovered so far, CB 1 (2.1: CBD: 1: CB1:),
cloned in 1990, and CB 2 (2.1: CBD: 2: CB2:), cloned in 1993. Distinction between these …

Unconventional high-value products from microalgae: A review

S Abu-Ghosh, Z Dubinsky, V Verdelho, D Iluz - Bioresource Technology, 2021 - Elsevier
Microalgae have gained significant importance in biotechnology development, providing
valuable goods and services in multiple applications. Although there is a rising market for …

[HTML][HTML] Endocannabinoid-mediated control of synaptic transmission

M Kano, T Ohno-Shosaku… - Physiological …, 2009 - journals.physiology.org
The discovery of cannabinoid receptors and subsequent identification of their endogenous
ligands (endocannabinoids) in early 1990s have greatly accelerated research on …

The endocannabinoid system as an emerging target of pharmacotherapy

P Pacher, S Bátkai, G Kunos - Pharmacological reviews, 2006 - Elsevier
The recent identification of cannabinoid receptors and their endogenous lipid ligands has
triggered an exponential growth of studies exploring the endocannabinoid system and its …