Abstract Cannon, Barbara, and Jan Nedergaard. Brown Adipose Tissue: Function and
Physiological Significance. Physiol Rev 84: 277–359, 2004; 10.1152/physrev. 00015.2003 …

Mitochondrial fusion, fission, and mitophagy form an essential axis of mitochondrial quality
control. However, quality control might not be the only task carried out by mitochondrial …

The goal of this review is to place the exciting advances that have occurred in our
understanding of the molecular biology of the types 1, 2, and 3 (D1, D2, and D3 …

Summary Mitochondrial uncoupling protein 1 (UCP1) is responsible for nonshivering
thermogenesis in brown adipose tissue (BAT). Upon activation by long-chain fatty acids …

Mitochondria play a central role in the survival and death of neurons. The detailed
bioenergetic mechanisms by which isolated mitochondria generate ATP, sequester Ca2+ …

Known for over a century, mitochondria have become during the last three decades an
important subject of research within several disciplines of experimental biology. For the …

Uncoupling protein (UCP) 1 is an integral membrane protein that is located in the
mitochondrial inner membrane of brown adipocytes. Its physiological role is to mediate a …

Although I had hoped that the chemiosmotic rationale of vectorial metabolism and biological
energy transfer might one day come to be generally accepted, it would have been …

The uniqueness of UCP1 (as compared to UCP2/UCP3) is evident from expression analysis
and ablation studies. UCP1 expression is positively correlated with metabolic inefficiency …

Mitochondria couple respiration to ATP synthesis through an electrochemical proton
gradient. Proton leak across the inner membrane allows adjustment of the coupling …