Microbiome and human health: current understanding, engineering, and enabling technologies
The human microbiome is composed of a collection of dynamic microbial communities that
inhabit various anatomical locations in the body. Accordingly, the coevolution of the …
inhabit various anatomical locations in the body. Accordingly, the coevolution of the …
The microbiome extends host evolutionary potential
The microbiome shapes many host traits, yet the biology of microbiomes challenges
traditional evolutionary models. Here, we illustrate how integrating the microbiome into …
traditional evolutionary models. Here, we illustrate how integrating the microbiome into …
Gut microbial metabolism of 5-ASA diminishes its clinical efficacy in inflammatory bowel disease
For decades, variability in clinical efficacy of the widely used inflammatory bowel disease
(IBD) drug 5-aminosalicylic acid (5-ASA) has been attributed, in part, to its acetylation and …
(IBD) drug 5-aminosalicylic acid (5-ASA) has been attributed, in part, to its acetylation and …
The gut microbiome modulates the protective association between a Mediterranean diet and cardiometabolic disease risk
To address how the microbiome might modify the interaction between diet and
cardiometabolic health, we analyzed longitudinal microbiome data from 307 male …
cardiometabolic health, we analyzed longitudinal microbiome data from 307 male …
[HTML][HTML] Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases
Inflammatory bowel diseases, which include Crohn's disease and ulcerative colitis, affect
several million individuals worldwide. Crohn's disease and ulcerative colitis are complex …
several million individuals worldwide. Crohn's disease and ulcerative colitis are complex …
Microbial genes and pathways in inflammatory bowel disease
Perturbations in the intestinal microbiome are implicated in inflammatory bowel disease
(IBD). Studies of treatment-naive patients have identified microbial taxa associated with …
(IBD). Studies of treatment-naive patients have identified microbial taxa associated with …
Species-level functional profiling of metagenomes and metatranscriptomes
Functional profiles of microbial communities are typically generated using comprehensive
metagenomic or metatranscriptomic sequence read searches, which are time-consuming …
metagenomic or metatranscriptomic sequence read searches, which are time-consuming …
Best practices for analysing microbiomes
Complex microbial communities shape the dynamics of various environments, ranging from
the mammalian gastrointestinal tract to the soil. Advances in DNA sequencing technologies …
the mammalian gastrointestinal tract to the soil. Advances in DNA sequencing technologies …
Gut microbiome, big data and machine learning to promote precision medicine for cancer
The gut microbiome has been implicated in cancer in several ways, as specific microbial
signatures are known to promote cancer development and influence safety, tolerability and …
signatures are known to promote cancer development and influence safety, tolerability and …
The progress of gut microbiome research related to brain disorders
There is increasing evidence showing that the dynamic changes in the gut microbiota can
alter brain physiology and behavior. Cognition was originally thought to be regulated only by …
alter brain physiology and behavior. Cognition was originally thought to be regulated only by …