Zebrafish (Danio rerio) larvae are widely recognized for studying host–pathogen interactions
in vivo because of their optical transparency, genetic manipulability, and translational …

The study of host–pathogen interactions has illuminated fundamental research avenues in
both infection and cell biology. Zebrafish (Danio rerio) larvae are genetically tractable …

Highlights•Intraperitoneal Shigella infection is often used but lacks physiological
relevance.•The zebrafish larvae model is best for imaging studies.•The streptomycin-Nlrc4 …

Innate immune defense against intracellular pathogens, like Salmonella, relies heavily on
the autophagy machinery of the host. This response is studied intensively in epithelial cells …

Pyroptosis, a regulated form of pro-inflammatory cell death, is characterised by cell lysis and
by the release of cytokines, damage-and pathogen-associated molecular patterns. It plays …

Autophagy is a conserved intracellular degradation process enclosing the bulk of cytosolic
components for lysosomal degradation to maintain cellular homeostasis. Accumulating …

Trained immunity is a long-term memory of innate immune cells, generating an improved
response upon reinfection. Shigella is an important human pathogen and inflammatory …

Interbacterial competition is known to shape the microbial communities found in the host,
however the interplay between this competition and host defense are less clear. Here, we …

We investigated the effects of dietary supplementation with Lactobacillus acidophilus and
Bacillus subtilis on the intestinal immune response, intestinal barrier function, cecal …

Abstract Interferon-gamma (IFN-γ) signaling is necessary for the proinflammatory activation
of macrophages but IFN-γ-independent pathways, for which the initiating stimuli and …