Materials for oral delivery of proteins and peptides

TD Brown, KA Whitehead, S Mitragotri - Nature Reviews Materials, 2020 - nature.com
Throughout history, oral administration has been regarded as the most convenient mode of
drug delivery, as it requires minimal expertise and invasiveness. Although oral delivery …

[HTML][HTML] Thiolated polymeric hydrogels for biomedical application: Cross-linking mechanisms

S Summonte, GF Racaniello, A Lopedota… - Journal of Controlled …, 2021 - Elsevier
This review focuses on the synthesis of hydrogel networks using thiomers such as thiolated
hyaluronic acid, chitosan, cyclodextrin, poly (ethylene glycol) and dextran that are cross …

Thiolated polymers: Bioinspired polymers utilizing one of the most important bridging structures in nature

C Leichner, M Jelkmann… - Advanced Drug Delivery …, 2019 - Elsevier
Thiolated polymers designated “thiomers” are obtained by covalent attachment of thiol
functionalities on the polymeric backbone of polymers. In 1998 these polymers were first …

Thiolation of biopolymers for develo** drug delivery systems with enhanced mechanical and mucoadhesive properties: A review

V Puri, A Sharma, P Kumar, I Singh - Polymers, 2020 - mdpi.com
Biopolymers are extensively used for develo** drug delivery systems as they are easily
available, economical, readily modified, nontoxic, biodegradable and biocompatible …

Xyloglucan: A functional biomacromolecule for drug delivery applications

AD Kulkarni, AA Joshi, CL Patil, PD Amale… - International Journal of …, 2017 - Elsevier
The near future of drug delivery system would lie in the search of a versatile and innocuous
material, based mostly on the natural resources. The tamarind seed xyloglucan (XG) is a …

Local drug delivery systems for inflammatory diseases: Status quo, challenges, and opportunities

YC Chen, SF Gad, D Chobisa, Y Li, Y Yeo - Journal of Controlled Release, 2021 - Elsevier
Inflammation that is not resolved in due course becomes a chronic disease. The treatment of
chronic inflammatory diseases involves a long-term use of anti-inflammatory drugs such as …

Functionalized and graft copolymers of chitosan and its pharmaceutical applications

C Bhavsar, M Momin, S Gharat… - Expert Opinion on Drug …, 2017 - Taylor & Francis
Introduction: Chitosan is the second most abundant natural polysaccharide. It belongs a
family of polycationic polymers comprised of repetitive units of glucosamine and N …

Preparation and characterization of chitosan-alginate microspheres loaded with quercetin

OD Frenț, N Duteanu, AC Teusdea, S Ciocan, L Vicaș… - Polymers, 2022 - mdpi.com
The aim of this paper was to formulate microspheres based on biodegradable polymers
(chitosan and sodium alginate), using the complex coacervation technique. Subsequently …

Protected thiol strategies in macromolecular design

F Goethals, D Frank, F Du Prez - Progress in Polymer Science, 2017 - Elsevier
Reactions involving thiols have been extensively applied in numerous polymeric systems
thanks to the reactive nature of the mercapto group, causing these reactions to be efficient …

Granular disulfide-crosslinked hyaluronic hydrogels: a systematic study of reaction conditions on thiol substitution and injectability parameters

LA Pérez, R Hernández, JM Alonso, R Pérez-González… - Polymers, 2023 - mdpi.com
Granular polymer hydrogels based on dynamic covalent bonds are attracting a great deal of
interest for the design of injectable biomaterials. Such materials generally exhibit shear …