[HTML][HTML] Properties and behavior of carbon nanomaterials when interfacing neuronal cells: How far have we come?
In the last two decades, an increasing amount of studies have investigated the use of
components based on carbon-(nano) materials in the engineering of neural interfaces, to …
components based on carbon-(nano) materials in the engineering of neural interfaces, to …
Role of Rad51 and DNA repair in cancer: A molecular perspective
The maintenance of genome integrity is essential for any organism survival and for the
inheritance of traits to offspring. To the purpose, cells have developed a complex DNA repair …
inheritance of traits to offspring. To the purpose, cells have developed a complex DNA repair …
[HTML][HTML] Efficient embryonic homozygous gene conversion via RAD51-enhanced interhomolog repair
Searching for factors to improve knockin efficiency for therapeutic applications,
biotechnology, and generation of non-human primate models of disease, we found that the …
biotechnology, and generation of non-human primate models of disease, we found that the …
Inhibition of FAM46/TENT5 activity by BCCIPα adopting a unique fold
The FAM46 (also known as TENT5) proteins are noncanonical poly (A) polymerases (PAPs)
implicated in regulating RNA stability. The regulatory mechanisms of FAM46 are poorly …
implicated in regulating RNA stability. The regulatory mechanisms of FAM46 are poorly …
Guardians of the genome: BRCA2 and its partners
HP Le, WD Heyer, J Liu - Genes, 2021 - mdpi.com
The tumor suppressor BRCA2 functions as a central caretaker of genome stability, and
individuals who carry BRCA2 mutations are predisposed to breast, ovarian, and other …
individuals who carry BRCA2 mutations are predisposed to breast, ovarian, and other …
Metadherin (AEG-1/MTDH/LYRIC) expression: significance in malignancy and crucial role in colorectal cancer
Abstract Metadherin (AEG-1/MTDH/LYRIC) is a 582-amino acid transmembrane protein,
encoded by a gene located at chromosome 8q22, and distributed throughout the cytoplasm …
encoded by a gene located at chromosome 8q22, and distributed throughout the cytoplasm …
RADX controls RAD51 filament dynamics to regulate replication fork stability
The RAD51 recombinase forms nucleoprotein filaments to promote double-strand break
repair, replication fork reversal, and fork stabilization. The stability of these filaments is highly …
repair, replication fork reversal, and fork stabilization. The stability of these filaments is highly …
Human RAD51 rapidly forms intrinsically dynamic nucleoprotein filaments modulated by nucleotide binding state
M Špírek, J Mlčoušková, O Beláň… - Nucleic Acids …, 2018 - academic.oup.com
Formation of RAD51 filaments on single-stranded DNA is an essential event during
homologous recombination, which is required for homology search, strand exchange and …
homologous recombination, which is required for homology search, strand exchange and …
[HTML][HTML] Putting together and taking apart: assembly and disassembly of the Rad51 nucleoprotein filament in DNA repair and genome stability
T Andriuskevicius, O Kotenko, S Makovets - Cell Stress, 2018 - ncbi.nlm.nih.gov
Homologous recombination is a key mechanism providing both genome stability and
genetic diversity in all living organisms. Recombinases play a central role in this pathway …
genetic diversity in all living organisms. Recombinases play a central role in this pathway …
Medulloblastomas Initiated by Homologous Recombination Defects in Mice
H Lu, Y Wang, S Chaudhary, V Balaga, H Ke… - The American Journal of …, 2024 - Elsevier
Germline mutations of homologous-recombination (HR) genes are among the top
contributors to medulloblastomas. A significant portion of human medulloblastomas exhibit …
contributors to medulloblastomas. A significant portion of human medulloblastomas exhibit …