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The journey from melanocytes to melanoma
Over the past decade, melanoma has led the field in new cancer treatments, with impressive
gains in on-treatment survival but more modest improvements in overall survival. Melanoma …
gains in on-treatment survival but more modest improvements in overall survival. Melanoma …
Signal pathways of melanoma and targeted therapy
W Guo, H Wang, C Li - Signal transduction and targeted therapy, 2021 - nature.com
Melanoma is the most lethal skin cancer that originates from the malignant transformation of
melanocytes. Although melanoma has long been regarded as a cancerous malignancy with …
melanocytes. Although melanoma has long been regarded as a cancerous malignancy with …
RAS-targeted therapies: is the undruggable drugged?
Abstract RAS (KRAS, NRAS and HRAS) is the most frequently mutated gene family in
cancers, and, consequently, investigators have sought an effective RAS inhibitor for more …
cancers, and, consequently, investigators have sought an effective RAS inhibitor for more …
[HTML][HTML] Dissecting the treatment-naive ecosystem of human melanoma brain metastasis
Melanoma brain metastasis (MBM) frequently occurs in patients with advanced melanoma;
yet, our understanding of the underlying salient biology is rudimentary. Here, we performed …
yet, our understanding of the underlying salient biology is rudimentary. Here, we performed …
Ectopic JAK–STAT activation enables the transition to a stem-like and multilineage state conferring AR-targeted therapy resistance
Emerging evidence indicates that various cancers can gain resistance to targeted therapies
by acquiring lineage plasticity. Although various genomic and transcriptomic aberrations …
by acquiring lineage plasticity. Although various genomic and transcriptomic aberrations …
[HTML][HTML] Molecular markers and targets in melanoma
C Teixido, P Castillo, C Martinez-Vila, A Arance, L Alos - Cells, 2021 - mdpi.com
Melanoma develops as a result of several genetic alterations, with UV radiation often acting
as a mutagenic risk factor. Deep knowledge of the molecular signaling pathways of different …
as a mutagenic risk factor. Deep knowledge of the molecular signaling pathways of different …
[HTML][HTML] Aetiology and pathogenesis of cutaneous melanoma: current concepts and advances
Melanoma develops from malignant transformations of the pigment-producing melanocytes.
If located in the basal layer of the skin epidermis, melanoma is referred to as cutaneous …
If located in the basal layer of the skin epidermis, melanoma is referred to as cutaneous …
The spatial landscape of progression and immunoediting in primary melanoma at single-cell resolution
Cutaneous melanoma is a highly immunogenic malignancy that is surgically curable at early
stages but life-threatening when metastatic. Here we integrate high-plex imaging, 3D high …
stages but life-threatening when metastatic. Here we integrate high-plex imaging, 3D high …
MITF—the first 25 years
CR Goding, H Arnheiter - Genes & development, 2019 - genesdev.cshlp.org
All transcription factors are equal, but some are more equal than others. In the 25 yr since
the gene encoding the microphthalmia-associated transcription factor (MITF) was first …
the gene encoding the microphthalmia-associated transcription factor (MITF) was first …
[HTML][HTML] Targeting OXPHOS and the electron transport chain in cancer; Molecular and therapeutic implications
Oxidative phosphorylation (OXPHOS) takes place in mitochondria and is the process
whereby cells use carbon fuels and oxygen to generate ATP. Formerly OXPHOS was …
whereby cells use carbon fuels and oxygen to generate ATP. Formerly OXPHOS was …