Histone deacetylases (HDACs): evolution, specificity, role in transcriptional complexes, and pharmacological actionability
Histone deacetylases (HDACs) are evolutionary conserved enzymes which operate by
removing acetyl groups from histones and other protein regulatory factors, with functional …
removing acetyl groups from histones and other protein regulatory factors, with functional …
Genetics and epigenetics in asthma
P Ntontsi, A Photiades, E Zervas, G Xanthou… - International journal of …, 2021 - mdpi.com
Asthma is one of the most common respiratory disease that affects both children and adults
worldwide, with diverse phenotypes and underlying pathogenetic mechanisms poorly …
worldwide, with diverse phenotypes and underlying pathogenetic mechanisms poorly …
Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders
KJ Falkenberg, RW Johnstone - Nature reviews Drug discovery, 2014 - nature.com
Epigenetic aberrations, which are recognized as key drivers of several human diseases, are
often caused by genetic defects that result in functional deregulation of epigenetic proteins …
often caused by genetic defects that result in functional deregulation of epigenetic proteins …
Histone deacetylases as regulators of inflammation and immunity
Histone deacetylases (HDACs) remove an acetyl group from lysine residues of target
proteins to regulate cellular processes. Small-molecule inhibitors of HDACs cause cellular …
proteins to regulate cellular processes. Small-molecule inhibitors of HDACs cause cellular …
Histone deacetylases and mechanisms of regulation of gene expression
HP Chen, YT Zhao, TC Zhao - Critical Reviews™ in …, 2015 - dl.begellhouse.com
In recent years it has become widely recognized that histone modification plays a pivotal
role in controlling gene expression and is involved in a wide spectrum of disease regulation …
role in controlling gene expression and is involved in a wide spectrum of disease regulation …
[HTML][HTML] Histone deacetylases and their inhibitors in inflammatory diseases
SY Zhang, LY Zhang, R Wen, N Yang… - Biomedicine & …, 2024 - Elsevier
Despite considerable research efforts, inflammatory diseases remain a heavy burden on
human health, causing significant economic losses annually. Histone deacetylases …
human health, causing significant economic losses annually. Histone deacetylases …
Histone deacetylase function in CD4+ T cells
The differentiation of T helper cell subsets and their acquisition of effector functions are
accompanied by changes in gene expression programmes, which in part are regulated and …
accompanied by changes in gene expression programmes, which in part are regulated and …
Treatment of allergic asthma: modulation of Th2 cells and their responses
B Bosnjak, B Stelzmueller, KJ Erb, MM Epstein - Respiratory research, 2011 - Springer
Atopic asthma is a chronic inflammatory pulmonary disease characterised by recurrent
episodes of wheezy, laboured breathing with an underlying Th2 cell-mediated inflammatory …
episodes of wheezy, laboured breathing with an underlying Th2 cell-mediated inflammatory …
Multiple roles of class I HDACs in proliferation, differentiation, and development
N Reichert, MA Choukrallah, P Matthias - Cellular and Molecular Life …, 2012 - Springer
Abstract Class I Histone deacetylases (HDACs) play a central role in controlling cell cycle
regulation, cell differentiation, and tissue development. These enzymes exert their function …
regulation, cell differentiation, and tissue development. These enzymes exert their function …
Histone deacetylase 1 and 2 are essential for normal T-cell development and genomic stability in mice
OM Dovey, CT Foster, N Conte… - Blood, The Journal …, 2013 - ashpublications.org
Abstract Histone deacetylase 1 and 2 (HDAC1/2) regulate chromatin structure as the
catalytic core of the Sin3A, NuRD and CoREST co-repressor complexes. To better …
catalytic core of the Sin3A, NuRD and CoREST co-repressor complexes. To better …