The burden of cardiovascular and metabolic diseases worldwide is staggering. The
emergence of systems approaches in biology promises new therapies, faster and cheaper …

Chemotherapy and targeted therapies have significantly improved the prognosis of
oncology patients. However, these antineoplastic treatments may also induce adverse …

Cardiomyocyte loss after injury results in adverse remodelling and fibrosis, inevitably
leading to heart failure. The ERBB2–Neuregulin and Hippo–YAP signalling pathways are …

Heart growth is tightly controlled so that the heart reaches a predetermined size. Fetal heart
growth occurs through cardiomyocyte proliferation, whereas postnatal heart growth involves …

Heart regeneration is limited in adult mammals but occurs naturally in adult zebrafish
through the activation of cardiomyocyte division. Several components of the cardiac injury …

The murine neonatal heart can regenerate after injury through cardiomyocyte (CM)
proliferation, although this capacity markedly diminishes after the first week of life …

Heart disease is the leading cause of death worldwide. Despite decades of research, most
heart pathologies have limited treatments, and often the only curative approach is heart …

The adult human heart does not regenerate significant amounts of lost tissue after injury.
Rather than making new, functional muscle, human hearts are prone to scarring and …

How diverse cell fates and complex forms emerge and feed back to each other to sculpt
functional organs remains unclear. In the develo** heart, the myocardium transitions from …

Whether left ventricular noncompaction (LVNC) is a distinct cardiomyopathy or a
morphologic trait shared by different cardiomyopathies remains controversial. Current …