The trRosetta (transform-restrained Rosetta) server is a web-based platform for fast and
accurate protein structure prediction, powered by deep learning and Rosetta. With the input …

Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …

The ConSurf web‐sever for the analysis of proteins, RNA, and DNA provides a quick and
accurate estimate of the per‐site evolutionary rate among homologues. The analysis reveals …

Bacteriophage (phage) taxonomy has been in flux since its inception over four decades ago.
Genome sequencing has put pressure on the classification system and recent years have …

Millions of new viral sequences have been identified from metagenomes, but the quality and
completeness of these sequences vary considerably. Here we present CheckV, an …

Personalized genome sequencing has revealed millions of genetic differences between
individuals, but our understanding of their clinical relevance remains largely incomplete. To …

Protein structure prediction can be used to determine the three-dimensional shape of a
protein from its amino acid sequence. This problem is of fundamental importance as the …

Summary The cyclic pyrimidines 3′, 5′-cyclic cytidine monophosphate (cCMP) and 3′,
5′-cyclic uridine monophosphate (cUMP) have been reported in multiple organisms and …

Maintaining a healthy proteome is fundamental for the survival of all organisms. Integral to
this are Hsp90 and Hsp70, molecular chaperones that together facilitate the folding …

Horizontal gene transfer can trigger rapid shifts in bacterial evolution. Driven by a variety of
mobile genetic elements—in particular bacteriophages and plasmids—the ability to share …